State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology , Dalian 116024, China.
Org Lett. 2017 Feb 17;19(4):946-949. doi: 10.1021/acs.orglett.7b00168. Epub 2017 Jan 31.
The first ferrous chloride catalyzed boration/β-fluorine elimination of trifluoromethyl alkenes is described. Thus, a full range of gem-difluoroallylboronates were obtained in high yield under mild conditions. As an important fluorinated building block, gem-difluoroallylboronate can be readily converted into diverse difluoro-substituted species.
首次描述了三氟甲基烯烃的亚铁氯化物催化硼化/β-氟消除反应。因此，在温和条件下，以高产率得到了全系列的偕二氟烯丙基硼酸酯。作为一种重要的氟化砌块，偕二氟烯丙基硼酸酯可以很容易地转化为多种二氟取代的化合物。
