Bassett A S
Department of Psychiatry, Columbia University, New York, NY.
Schizophr Bull. 1989;15(3):393-402. doi: 10.1093/schbul/15.3.393.
Two years ago, a family with two members who shared a chromosomal anomaly (partial trisomy of the long arm of chromosome 5), mild physical abnormalities, and schizophrenia was reported. This special family provided a candidate region on chromosome 5 for linkage studies of schizophrenia. The background of the finding is examined, and the specific features of the original report are outlined. A description of the immediate implications of the chromosome 5 abnormality for linkage studies leads to a discussion of the broader clinical, methodological, and ethical issues involved. Solutions to the many questions arising from this new wave of genetic linkage studies will require active involvement of researchers, clinicians, and families.
两年前，有报道称一个有两名成员的家庭存在染色体异常（5号染色体长臂部分三体）、轻度身体异常和精神分裂症。这个特殊的家庭为精神分裂症的连锁研究提供了5号染色体上的一个候选区域。本文审视了这一发现的背景，并概述了原始报告的具体特征。对5号染色体异常对连锁研究的直接影响的描述引发了对所涉及的更广泛的临床、方法学和伦理问题的讨论。要解决这新一轮基因连锁研究中出现的诸多问题，需要研究人员、临床医生和家庭的积极参与。
