Suppr超能文献

将DNA标记物定位到与精神分裂症共分离的5号染色体区域的缺失作图。

Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia.

作者信息

Gilliam T C, Freimer N B, Kaufmann C A, Powchik P P, Bassett A S, Bengtsson U, Wasmuth J J

机构信息

Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York 10032.

出版信息

Genomics. 1989 Nov;5(4):940-4. doi: 10.1016/0888-7543(89)90138-9.

DOI:10.1016/0888-7543(89)90138-9
PMID:2591972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3154173/
Abstract

Two independent lines of evidence support the localization of a schizophrenia susceptibility locus to the proximal long arm of chromosome 5. A partial trisomy of chromosome 5 (5q11.2-q13.3) cosegregates with the disorder in a Canadian family of Chinese descent, and DNA markers from proximal 5q cosegregate with schizophrenia (plus related disorders) in families of British and Icelandic descent. We constructed a human:hamster hybrid cell line (HHW 1064) whose only human complement is a chromosome 5 that is missing the trisomic region associated with schizophrenia. In combination with a "matched" cell hybrid (HHW 105) containing an intact chromosome 5, we physically mapped DNA markers relative to the trisomy. "Schizophrenia-linked" DNA markers p105-153Ra (D5S39) and p105-599Ha (D5S76) map within the trisomy and proximal to the 5q11.2 breakpoint, respectively. The hybrid cell lines HHW 105 and HHW 1064 together provide a means to identify and generate syntenic DNA markers to further investigate the location of a schizophrenia locus.

摘要

两条独立的证据线索支持精神分裂症易感基因座定位于5号染色体长臂近端。在一个华裔加拿大家庭中，5号染色体部分三体（5q11.2-q13.3）与该疾病共分离，并且来自5q近端的DNA标记在英裔和冰岛裔家庭中与精神分裂症（以及相关疾病）共分离。我们构建了一个人-仓鼠杂交细胞系（HHW 1064），其唯一的人类成分是一条缺失与精神分裂症相关的三体区域的5号染色体。结合一个含有完整5号染色体的“匹配”细胞杂种（HHW 105），我们相对于三体对DNA标记进行了物理定位。“精神分裂症相关”DNA标记p105-153Ra（D5S39）和p105-599Ha（D5S76）分别定位于三体内部且靠近5q11.2断点的位置。杂交细胞系HHW 105和HHW 1064共同提供了一种识别和生成同线DNA标记的方法，以进一步研究精神分裂症基因座的位置。

相似文献

1
Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia.将DNA标记物定位到与精神分裂症共分离的5号染色体区域的缺失作图。
Genomics. 1989 Nov;5(4):940-4. doi: 10.1016/0888-7543(89)90138-9.
2
Physical mapping, linkage analysis of a putative schizophrenia locus on chromosome 5q.5号染色体长臂上一个假定的精神分裂症基因座的物理图谱构建及连锁分析。
Schizophr Bull. 1989;15(3):441-52. doi: 10.1093/schbul/15.3.441.
3
No linkage of chromosome 5q11-q13 markers to schizophrenia in Scottish families.在苏格兰家庭中，5号染色体q11 - q13区域的标记与精神分裂症无连锁关系。
Nature. 1989 May 25;339(6222):305-9. doi: 10.1038/339305a0.
4
New DNA markers with increased informativeness show diminished support for a chromosome 5q11-13 schizophrenia susceptibility locus and exclude linkage in two new cohorts of British and Icelandic families.信息性增强的新型DNA标记显示，对5号染色体q11 - 13区域精神分裂症易感基因座的支持减弱，并排除了两个英国和冰岛新家族队列中的连锁关系。
Ann Hum Genet. 1999 May;63(Pt 3):235-47. doi: 10.1046/j.1469-1809.1999.6330235.x.
5
Failure to replicate linkage between chromosome 5q11-q13 markers and schizophrenia in 28 families.在28个家庭中未能复制5号染色体q11 - q13区域标记与精神分裂症之间的连锁关系。
Psychiatry Res. 1992 Dec;44(3):171-9. doi: 10.1016/0165-1781(92)90021-t.
6
Lack of linkage to chromosome 5q11-q13 markers in six schizophrenia pedigrees.六个精神分裂症家系中与5号染色体q11-q13标记无连锁关系
Arch Gen Psychiatry. 1991 Apr;48(4):357-61. doi: 10.1001/archpsyc.1991.01810280073010.
7
Exclusion of a schizophrenia susceptibility gene from the chromosome 5q11-q13 region: new data and a reanalysis of previous reports.排除5号染色体q11-q13区域的精神分裂症易感基因：新数据及对既往报告的重新分析
Am J Hum Genet. 1990 Sep;47(3):524-35.
8
Large linkage analysis in 100 families with autosomal recessive spinal muscular atrophy (SMA) and 11 CEPH families using 15 polymorphic loci in the region 5q11.2-q13.3.在100个常染色体隐性遗传性脊髓性肌萎缩症（SMA）家庭以及11个CEPH家庭中，利用位于5q11.2-q13.3区域的15个多态性位点进行大型连锁分析。
Genomics. 1994 Mar 1;20(1):84-93. doi: 10.1006/geno.1994.1130.
9
Microsatellite polymorphisms for chromosome 5 bands q11.2-q13.3.5号染色体q11.2-q13.3区域的微卫星多态性
Hum Hered. 1993 May-Jun;43(3):197-202. doi: 10.1159/000154177.
10
A cosmid clone for the 5HT1A receptor (HTR1A) reveals a TaqI RFLP that shows tight linkage to dna loci D5S6, D5S39, and D5S76.一种用于5-羟色胺1A受体（HTR1A）的黏粒克隆揭示了一种TaqI限制性片段长度多态性，该多态性与DNA位点D5S6、D5S39和D5S76紧密连锁。
Genomics. 1991 Nov;11(3):767-9. doi: 10.1016/0888-7543(91)90088-v.

引用本文的文献

1
Discovery of Natural Product-Derived 5-HT1A Receptor Binders by Cheminfomatics Modeling of Known Binders, High Throughput Screening and Experimental Validation.通过已知结合剂的化学信息学建模、高通量筛选和实验验证发现天然产物衍生的5-HT1A受体结合剂。
Comb Chem High Throughput Screen. 2015;18(7):685-92. doi: 10.2174/1386207318666150703113948.
2
Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism.酗酒家族中对语义启动范式产生反应的事件相关脑电位的遗传学研究。
Am J Hum Genet. 2001 Jan;68(1):128-135. doi: 10.1086/316936. Epub 2000 Dec 1.
3
Regional localization of the rat genes encoding the cAMP-specific phosphodiesterases 3 (Pde4d) and 4 (Pde4b) and the tyrosinase-related protein 1 (Tyrp1).编码环磷酸腺苷特异性磷酸二酯酶3（Pde4d）、4（Pde4b）和酪氨酸酶相关蛋白1（Tyrp1）的大鼠基因的区域定位。
Mamm Genome. 1996 Mar;7(3):222-3. doi: 10.1007/s003359900060.
4
A sublocus of the multicopy microsatellite marker CMS1 maps proximal to spinal muscular atrophy (SMA) as shown by recombinant analysis.重组分析显示，多拷贝微卫星标记CMS1的一个亚位点定位于脊髓性肌萎缩症（SMA）近端。
Hum Genet. 1995 Nov;96(5):589-91. doi: 10.1007/BF00197416.
5
Cosegregation of schizophrenia with Becker muscular dystrophy: susceptibility locus for schizophrenia at Xp21 or an effect of the dystrophin gene in the brain?精神分裂症与贝克型肌营养不良的共分离：Xp21 上的精神分裂症易感基因座还是抗肌萎缩蛋白基因在大脑中的作用？
J Med Genet. 1993 Feb;30(2):131-4. doi: 10.1136/jmg.30.2.131.
6
Two novel microsatellite markers for prenatal prediction of spinal muscular atrophy (SMA).用于脊髓性肌萎缩症（SMA）产前预测的两种新型微卫星标记物。
Hum Genet. 1993 Sep;92(2):133-8. doi: 10.1007/BF00219680.
7
Construction of a yeast artificial chromosome contig spanning the spinal muscular atrophy disease gene region.跨越脊髓性肌萎缩症疾病基因区域的酵母人工染色体重叠群的构建。
Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6801-5. doi: 10.1073/pnas.90.14.6801.
8
Paternal duplication of chromosome 5q11.2-5q14 in a male born with craniostenosis, ear tags, kidney dysplasia and several other anomalies.一名患有颅骨狭窄、耳赘、肾发育不全及其他多种异常的男性患儿存在5号染色体q11.2 - 5q14区域的父源重复。
Hum Genet. 1993 Nov;92(5):481-5. doi: 10.1007/BF00216455.
9
Mapping of two new markers within the smallest interval harboring the spinal muscular atrophy locus by family and radiation hybrid analysis.通过家系分析和辐射杂种分析在包含脊髓性肌萎缩症基因座的最小区间内定位两个新标记。
Hum Genet. 1994 May;93(5):494-501. doi: 10.1007/BF00202811.
10
Use of genetic and physical mapping to locate the spinal muscular atrophy locus between two new highly polymorphic DNA markers.利用遗传和物理图谱将脊髓性肌萎缩基因座定位在两个新的高度多态性DNA标记之间。
Am J Hum Genet. 1994 Apr;54(4):687-94.

本文引用的文献

1
Selective linkage disruption in human-Chinese hamster cell hybrids: deletion mapping of the leuS, hexB, emtB, and chr genes on human chromosome 5.人-中国仓鼠细胞杂种中的选择性连锁破坏：人类5号染色体上leuS、hexB、emtB和chr基因的缺失定位
Mol Cell Biol. 1982 Oct;2(10):1220-8. doi: 10.1128/mcb.2.10.1220-1228.1982.
2
The functional human dihydrofolate reductase gene.功能性人类二氢叶酸还原酶基因。
J Biol Chem. 1984 Mar 25;259(6):3933-43.
3
The gene for familial polyposis coli maps to the long arm of chromosome 5.家族性结肠息肉病基因定位于5号染色体长臂。
Science. 1987 Dec 4;238(4832):1411-3. doi: 10.1126/science.3479843.
4
An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins.一个无内含子基因，编码一种与鸟嘌呤核苷酸调节蛋白偶联的受体家族的潜在成员。
Nature. 1987;329(6134):75-9. doi: 10.1038/329075a0.
5
Approaches to physical mapping of the human genome.人类基因组物理图谱绘制方法。
Cold Spring Harb Symp Quant Biol. 1986;51 Pt 1:115-22. doi: 10.1101/sqb.1986.051.01.014.
6
Genomic analysis II: isolation of high molecular weight heteroduplex DNA following differential methylase protection and Formamide-PERT hybridization.基因组分析II：差异甲基化酶保护和甲酰胺-引物延伸反应杂交后高分子量异源双链DNA的分离
Nucleic Acids Res. 1986 Sep 25;14(18):7285-303. doi: 10.1093/nar/14.18.7285.
7
Isolation of cDNA clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on Tay-Sachs disease.编码人β-己糖胺酶α亚基的cDNA克隆的分离。α亚基和β亚基之间的广泛同源性以及对泰-萨克斯病的研究。
J Biol Chem. 1986 Jun 25;261(18):8407-13.
8
An anonymous human single copy genomic clone, D5S6 (M4) on chromosome 5 identifies a three allele RFLP.一个位于5号染色体上的匿名人类单拷贝基因组克隆D5S6（M4）可识别出一种三等位基因限制性片段长度多态性。
Nucleic Acids Res. 1986 Feb 25;14(4):1923. doi: 10.1093/nar/14.4.1923.
9
Specific cloning of DNA fragments absent from the DNA of a male patient with an X chromosome deletion.对一名患有X染色体缺失的男性患者DNA中缺失的DNA片段进行特异性克隆。
Proc Natl Acad Sci U S A. 1985 Jul;82(14):4778-82. doi: 10.1073/pnas.82.14.4778.
10
Glucocorticoid receptor maps to the distal long arm of chromosome 5.糖皮质激素受体定位于5号染色体长臂远端。
Cytogenet Cell Genet. 1988;49(4):313-4. doi: 10.1159/000132686.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验