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靶向L型氨基酸转运体的癌症治疗新方法。

Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment.

作者信息

Hayashi Keitaro, Anzai Naohiko

机构信息

Keitaro Hayashi, Naohiko Anzai, Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Shimotsuga, Tochigi 321-0293, Japan.

出版信息

World J Gastrointest Oncol. 2017 Jan 15;9(1):21-29. doi: 10.4251/wjgo.v9.i1.21.

DOI:10.4251/wjgo.v9.i1.21
PMID:28144396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5241523/
Abstract

L-type amino acid transporters (LATs) mainly assist the uptake of neutral amino acids into cells. Four LATs (LAT1, LAT2, LAT3 and LAT4) have so far been identified. LAT1 (SLC7A5) has been attracting much attention in the field of cancer research since it is commonly up-regulated in various cancers. Basic research has made it increasingly clear that LAT1 plays a predominant role in malignancy. The functional significance of LAT1 in cancer and the potential therapeutic application of the features of LAT1 to cancer management are described in this review.

摘要

L型氨基酸转运体（LATs）主要协助中性氨基酸进入细胞。目前已鉴定出四种LATs（LAT1、LAT2、LAT3和LAT4）。LAT1（SLC7A5）由于在各种癌症中普遍上调，在癌症研究领域备受关注。基础研究越来越清楚地表明，LAT1在恶性肿瘤中起主要作用。本文综述了LAT1在癌症中的功能意义以及LAT1特性在癌症治疗中的潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f0d/5241523/d58f98e6cd09/WJGO-9-21-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f0d/5241523/b564c2eb5264/WJGO-9-21-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f0d/5241523/d58f98e6cd09/WJGO-9-21-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f0d/5241523/b564c2eb5264/WJGO-9-21-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f0d/5241523/d58f98e6cd09/WJGO-9-21-g002.jpg

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LAT1 is a putative therapeutic target in endometrioid endometrial carcinoma.LAT1是子宫内膜样子宫内膜癌中一个假定的治疗靶点。
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