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比较[F]FIMP、[C]MET 和[F]FDG PET 在放疗早期疗效评估中的作用。

Comparison of [F]FIMP, [C]MET, and [F]FDG PET for early-phase assessment of radiotherapy response.

机构信息

Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, 6-7-3 Minatojima Minamimachi, Chuo-Ku, Kobe, Hyogo, 650-0047, Japan.

Novel PET Diagnostics Laboratory, RIKEN Innovation Center, Kobe, Hyogo, Japan.

出版信息

Sci Rep. 2023 Feb 3;13(1):1961. doi: 10.1038/s41598-023-29166-y.

DOI:10.1038/s41598-023-29166-y
PMID:36737550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9898523/
Abstract

Several limitations of [F]FDG have been reported, such as nonspecific uptake of inflammation foci. Moreover, [C]MET has been found to accumulate in normal and inflammatory tissues as well as tumors. To increase specificity to tumor tissues, PET probes with tumor-specific molecular targets have been actively developed. [F]FIMP was found to be highly accumulated in LAT1-positive tumors but not in inflamed tissue. The aim of this study was to explore whether [F]FIMP can be used for the early-phase evaluation of radiotherapy accompanied by inflammation, and compare its effectiveness with those of [C]MET and [F]FDG. Tumor uptake of [F]FIMP decreased at day 1 after irradiation, and remained low until day 14. Comparatively, that of [F]FDG initially decreased at day 3 but was transiently elevated at day 7 and then decreased again at day 10. Decreased tumor uptake of [C]MET was observed at day 10. In line with the uptake of [F]FIMP, the ratio of Ki-67 immuno-positive cells in tumor tissues significantly decreased at day 1, 7, and 10 as compared with that in the control. These findings suggest that [F]FIMP may be a PET probe involved in the early detection and prediction of radiotherapy efficacy, although further clarification is needed.

摘要

已报道了[F]FDG 的一些局限性，例如炎症灶的非特异性摄取。此外，已经发现[C]MET 在正常组织、炎症组织和肿瘤中都有积累。为了提高对肿瘤组织的特异性，已经积极开发了具有肿瘤特异性分子靶标的 PET 探针。[F]FIMP 被发现高度积聚在 LAT1 阳性肿瘤中，但不在炎症组织中积聚。本研究旨在探讨[F]FIMP 是否可用于伴有炎症的放射治疗的早期评估，并比较其与[C]MET 和[F]FDG 的效果。[F]FIMP 的肿瘤摄取在照射后第 1 天下降，并持续低至第 14 天。相比之下，[F]FDG 的摄取最初在第 3 天下降，但在第 7 天短暂升高，然后在第 10 天再次下降。[C]MET 的肿瘤摄取在第 10 天下降。与[F]FIMP 的摄取一致，与对照组相比，肿瘤组织中 Ki-67 免疫阳性细胞的比例在第 1、7 和 10 天显著下降。这些发现表明，[F]FIMP 可能是一种参与放射治疗效果早期检测和预测的 PET 探针，尽管需要进一步澄清。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c812/9898523/2f0c40ef13a5/41598_2023_29166_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c812/9898523/0208523cdaa8/41598_2023_29166_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c812/9898523/05d3c8b721a4/41598_2023_29166_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c812/9898523/1fe803afdf30/41598_2023_29166_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c812/9898523/04c62b17a213/41598_2023_29166_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c812/9898523/b3001257132b/41598_2023_29166_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c812/9898523/31ca7f9c4e87/41598_2023_29166_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c812/9898523/2f0c40ef13a5/41598_2023_29166_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c812/9898523/0208523cdaa8/41598_2023_29166_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c812/9898523/05d3c8b721a4/41598_2023_29166_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c812/9898523/1fe803afdf30/41598_2023_29166_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c812/9898523/04c62b17a213/41598_2023_29166_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c812/9898523/b3001257132b/41598_2023_29166_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c812/9898523/31ca7f9c4e87/41598_2023_29166_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c812/9898523/2f0c40ef13a5/41598_2023_29166_Fig7_HTML.jpg

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