Gonzalez Maria Cristina, Heymsfield Steven B
Postgraduate Program in Health and Behavior, Universidade Católica de Pelotas, Pelotas, RS, Brazil.
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, 70803, USA.
J Cachexia Sarcopenia Muscle. 2017 Apr;8(2):187-189. doi: 10.1002/jcsm.12159. Epub 2017 Jan 31.
As reference methods are not available for identifying low skeletal muscle mass in clinical practice, the European Group on Sarcopenia in Older People the Asian Working Group for Sarcopenia and the International Consensus for Cancer Cachexia guidelines accept bioelectrical impedance analysis (BIA) as an option for sarcopenia and cachexia assessment. Using different BIA equations, several components that represent 'muscularity' can be assessed. Total skeletal muscle mass or appendicular skeletal muscle mass normalized in relation to height (skeletal muscle mass index or appendicular skeletal muscle index, respectively) is the most common term used in the consensus. These terms are similar, but they should not be used as synonymous. Both terms can be used to define sarcopenia, but adequate equations and cut-off values should be used according to the studied population. However, there is a disagreement between the sarcopenia definition assessed by using BIA from the European Group on Sarcopenia in Older People and Cachexia Consensus, and this can lead to an overestimation of sarcopenia and, consequently, cachexia. An effort should be made to standardize the terminology employed by the Societies to define low muscularity and sarcopenia by using BIA. Future validation studies may show the need for specific cut-off values for each population using this method.
由于在临床实践中没有可用于识别低骨骼肌质量的参考方法,老年肌少症欧洲工作组、亚洲肌少症工作组和癌症恶病质国际共识指南都认可生物电阻抗分析(BIA)作为肌少症和恶病质评估的一种选择。使用不同的BIA方程,可以评估几个代表“肌肉量”的成分。相对于身高进行标准化的总骨骼肌质量或四肢骨骼肌质量(分别为骨骼肌质量指数或四肢骨骼肌指数)是共识中最常用的术语。这些术语相似,但不应将它们用作同义词。这两个术语都可用于定义肌少症,但应根据所研究的人群使用适当的方程和临界值。然而,老年肌少症和恶病质共识欧洲工作组使用BIA评估的肌少症定义之间存在分歧,这可能导致对肌少症进而对恶病质的高估。应该努力规范各学会使用BIA定义低肌肉量和肌少症时所采用的术语。未来的验证研究可能表明需要针对使用该方法的每个人群设定特定的临界值。