Postgraduate Program in Health and Behavior, Catholic University of Pelotas.
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.
Curr Opin Clin Nutr Metab Care. 2018 Sep;21(5):366-374. doi: 10.1097/MCO.0000000000000496.
Bioelectrical impedance analysis (BIA) is an accepted technique to estimate low muscle mass for sarcopenia diagnosis. However, muscularity assessment from BIA relies on prediction equations, estimating different compartments according to the calibration method. Low muscle mass can be defined using different approaches.
There is a lack of standardization on how low muscularity is defined in the context of sarcopenia. Recent studies have shown discrepant results for the estimation of low muscle mass when different prediction equations are used in the same BIA device. Different sarcopenia prevalence rates are observed if different definitions are used to identify low muscle mass. Most of the studies using BIA for diagnosing sarcopenia use the incorrect combination of specific population cut-off or a different device from the original equation.
The lack of standardization of BIA use for assessing muscularity results in a wide range of sarcopenia prevalence rates among studies, even when conducted in the same population. As BIA equations and cut-off values are population and device-specific, results should be interpreted with caution when data from different devices are applied in equations or using cut-off values from a different population.
生物电阻抗分析(BIA)是一种被认可的技术,可用于估计肌少症诊断中的低肌肉量。然而,BIA 对肌肉量的评估依赖于预测方程,根据校准方法估计不同的隔室。可以使用不同的方法来定义低肌肉量。
在肌少症的背景下,如何定义低肌肉量缺乏标准化。最近的研究表明,当在同一 BIA 设备中使用不同的预测方程时,低肌肉量的估计结果存在差异。如果使用不同的定义来识别低肌肉量,则观察到不同的肌少症患病率。大多数使用 BIA 诊断肌少症的研究使用特定人群的截定点或与原始方程不同的设备的错误组合。
BIA 用于评估肌肉量的使用缺乏标准化,导致即使在同一人群中,研究中的肌少症患病率也存在很大差异。由于 BIA 方程和截定点是特定于人群和设备的,因此当在方程中应用来自不同设备的数据或使用来自不同人群的截定点时,应谨慎解释结果。