一株海洋真菌 sp. SCSIO041218 的新型大环二萜和两种新型多环色酮
A New Macrodiolide and Two New Polycyclic Chromones from the Fungus sp. SCSIO041218.
机构信息
Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China.
Department of Pharmacy, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Institute of Infection, Immunology and Tumor Microenvironments, Medical College, Wuhan University of Science of Technology, Wuhan 430081, China.
出版信息
Molecules. 2019 Apr 30;24(9):1686. doi: 10.3390/molecules24091686.
A new macrodiolide, mangrovlide A () and two new polycyclic chromones, penixanthones C () and D (), as well as four other known compounds (-), have been isolated from the mangrove sediment derived fungus sp. SCSIO041218, cultured in the 0.25% NaCl rice substrate. The structures of the new compounds were determined by analysis of the NMR and MS spectroscopic data. Compound possesses a 10-membered macrodiolide unit, while and are chromones with an unprecedented 6/6/6/5 polycyclic skeleton. Compounds - were evaluated for their cytotoxicities, while all the compounds displayed weak or no activity.
从红树林沉积物中分离得到一株真菌，命名为 sp. SCSIO041218，在 0.25%NaCl 大米培养基中进行培养。从该真菌中分离得到一个新的大环二萜 mangrovlide A ()，两个新的多环色酮 penixanthones C () 和 D ()，以及另外四个已知化合物 (-)。通过 NMR 和 MS 光谱数据分析确定了新化合物的结构。化合物 含有一个 10 元大环二萜单元，而 和 是具有前所未有的 6/6/6/5 多环骨架的色酮。对化合物 - 进行了细胞毒性评价，而所有化合物均表现出较弱或无活性。
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