趋化因子在前列腺癌和肾癌中的活性及其作为未来治疗靶点的潜在作用。
Activity of chemokines in prostate and renal tumors and their potential role as future therapeutic targets.
作者信息
Cimadamore Alessia, Scarpelli Marina, Piva Francesco, Massari Francesco, Gasparrini Silvia, Doria Andrea, Cheng Liang, Lopez-Beltran Antonio, Montironi Rodolfo
机构信息
Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.
Department of Specialist Clinical & Odontostomatological Sciences, Università Politecnica delle Marche, Ancona, Italy.
出版信息
Future Oncol. 2017 May;13(12):1105-1114. doi: 10.2217/fon-2016-0481. Epub 2017 Feb 2.
Chemokines are a class of low-molecular-weight proteins that induce chemotaxis and are implicated in the modulation of angiogenesis. The imbalance among angiogenic and antiangiogenic chemokines can promote the development of several conditions, including chronic inflammation, dysplastic transformation and cancer. In this review, we describe the activity and clinical significance of chemokines in prostate and renal tumors and provide an update on ongoing studies in this setting.
趋化因子是一类能诱导趋化作用并参与血管生成调节的低分子量蛋白质。血管生成性趋化因子和抗血管生成性趋化因子之间的失衡可促进多种病症的发展，包括慢性炎症、发育异常转变和癌症。在本综述中，我们描述了趋化因子在前列腺肿瘤和肾肿瘤中的活性及临床意义，并提供了该领域正在进行的研究的最新情况。
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