Kharb Simmi, Kumawat Manjulata, Lallar Meenakshi, Ghalaut P S, Nanda Smiti
Department of Biochemistry, Pt. B.D. Sharma University of Health Sciences, PGIMS, House No. 22/8FM, Medical Campus, Rohtak, Haryana India.
Department of Obstetrics and Gynecology, Pt. B.D. Sharma University of Health Sciences, Rohtak, India.
Indian J Clin Biochem. 2017 Mar;32(1):95-98. doi: 10.1007/s12291-016-0571-z. Epub 2016 May 3.
HIV infects cluster of differentiation 4 (CD4) T-lymphocytes, monocytes and macrophages resulting in decreased number and function of CD4 cells, changes that affect both cell mediated and humoral immunity. Hematological abnormalities are a common complication of human immune virus (HIV) infection and these abnormalities increase as the disease advances. Anemia is the most common haematological abnormality in HIV seropositive patients and its incidence is strongly associated with the progression of the disease. The aim of present study was to assess the haematological profile of HIV seropositive women and compare them with CD4 count. Two hundred seropositive females (age 18-25 years) attending antiretroviral therapy clinic were selected. Routine gynaecological and haematological investigations were carried out, study samples were drawn and serum iron, folate and ferritin were analysed by chemiluminiscence and CD4 count was determined by using flow-cytometry. Anemia was prevalent in seropositive women especially in those with low CD4 levels. Serum folate and ferritin levels were significantly lower in females with lower CD4 levels. Serum iron levels were higher at low CD4 levels. The mean CD4 count in HIV seropositive anaemic women were lower as compared to non anaemics suggesting that anaemia improves with higher CD4 cell counts. Plasma folate and ferritin levels are sensitive predictor of anaemia in early HIV infections and these patients should have a regular monitoring of their folate and ferritin levels especially with lower CD4 levels.
人类免疫缺陷病毒（HIV）感染分化簇4（CD4）T淋巴细胞、单核细胞和巨噬细胞，导致CD4细胞数量减少和功能下降，这些变化会影响细胞介导免疫和体液免疫。血液学异常是人类免疫病毒（HIV）感染的常见并发症，且随着疾病进展这些异常会增加。贫血是HIV血清阳性患者中最常见的血液学异常，其发生率与疾病进展密切相关。本研究的目的是评估HIV血清阳性女性的血液学特征，并将其与CD4细胞计数进行比较。选取了200名在抗逆转录病毒治疗诊所就诊的血清阳性女性（年龄18 - 25岁）。进行了常规妇科和血液学检查，采集研究样本，通过化学发光法分析血清铁、叶酸和铁蛋白，使用流式细胞术测定CD4细胞计数。贫血在血清阳性女性中普遍存在，尤其是在CD4水平较低的女性中。CD4水平较低的女性血清叶酸和铁蛋白水平显著较低。CD4水平较低时血清铁水平较高。与非贫血的HIV血清阳性女性相比，贫血女性的平均CD4细胞计数较低，这表明随着CD4细胞计数升高贫血情况会改善。血浆叶酸和铁蛋白水平是早期HIV感染中贫血的敏感预测指标，这些患者应定期监测其叶酸和铁蛋白水平，尤其是在CD4水平较低时。
