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叶酸缺乏与黎巴嫩育龄妇女的营养性贫血有关。

Folate deficiency is associated with nutritional anaemia in Lebanese women of childbearing age.

作者信息

Al Khatib Lynn, Obeid Omar, Sibai Abla-Mehio, Batal Malek, Adra Nada, Hwalla Nahla

机构信息

Department of Nutrition and Food Science, Faculty of Agricultural and Food Sciences, American University of Beirut, PO Box 11-0236, Riad El Solh, Beirut 1107-2020, Lebanon.

出版信息

Public Health Nutr. 2006 Oct;9(7):921-7. doi: 10.1017/phn2005921.

DOI:10.1017/phn2005921
PMID:17010258
Abstract

OBJECTIVE

The objective of this study was to identify the determinants of anaemia in Lebanese women of childbearing age attending health centres in Lebanon.

DESIGN

Cross-sectional study carried out between May and December 2003. Anthropometric measurements as well as sociodemographic, health and dietary intake data were collected using a questionnaire. Haemoglobin (Hb), plasma ferritin, plasma folate and vitamin B12 were assessed using standard laboratory methods.

SETTING

Governmental health centres in Lebanon.

SUBJECTS

Four hundred and seventy non-pregnant Lebanese women aged 15-45 years.

RESULTS

Anaemia (Hb <12 g dl(-1)) and iron deficiency (ferritin <15 microg l(-1)) were prevalent in 16.0 and 27.2% of the study sample, respectively. Of the total sample, 7.7% had iron-deficiency anaemia. The percentage of women with either Hb or ferritin deficiency or both was 35.6%. Plasma folate and vitamin B12 deficiency was reported in 25.1 and 39.4%, respectively, and 12.6% of the women had both folate and vitamin B12 deficiencies. Of the anaemic group, 48.0% of the women had iron deficiency. The intake of iron was lower in iron-deficient than in non-deficient women and a positive relationship was shown between folate intake and its corresponding serum levels. Regression analysis showed that ferritin, plasma folate and family history of anaemia were significant determinants of the anaemia in the sample of women.

CONCLUSIONS

Anaemia not related to iron deficiency was partly explained by plasma folate deficiency. Measures to control folate and iron deficiency should be considered.

摘要

目的

本研究的目的是确定黎巴嫩育龄妇女在黎巴嫩保健中心就诊时贫血的决定因素。

设计

2003年5月至12月进行的横断面研究。使用问卷收集人体测量数据以及社会人口统计学、健康和饮食摄入数据。采用标准实验室方法评估血红蛋白(Hb)、血浆铁蛋白、血浆叶酸和维生素B12。

地点

黎巴嫩政府保健中心。

研究对象

470名15 - 45岁未怀孕的黎巴嫩妇女。

结果

贫血(Hb <12 g dl(-1))和缺铁(铁蛋白 <15 μg l(-1))在研究样本中分别占16.0%和27.2%。在整个样本中,7.7%患有缺铁性贫血。血红蛋白或铁蛋白缺乏或两者都缺乏的妇女比例为35.6%。血浆叶酸和维生素B12缺乏分别报告为25.1%和39.4%,12.6%的妇女同时存在叶酸和维生素B12缺乏。在贫血组中,48.0%的妇女缺铁。缺铁妇女的铁摄入量低于非缺铁妇女,叶酸摄入量与其相应血清水平之间呈正相关。回归分析表明,铁蛋白、血浆叶酸和贫血家族史是该妇女样本中贫血的重要决定因素。

结论

与缺铁无关的贫血部分可由血浆叶酸缺乏解释。应考虑采取措施控制叶酸和铁缺乏。

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