Živanović Marko N, Košarić Jelena V, Šmit Biljana, Šeklić Dragana S, Pavlović Radoslav Z, Marković Snežana D
Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia.
Gen Physiol Biophys. 2017 Apr;36(2):187-196. doi: 10.4149/gpb_2016036. Epub 2017 Feb 2.
Selenium and palladium containing compounds separately exert multifunctional effects on cells. While selenium containing compounds usually exert antioxidative properties, palladium(II) containing compounds are cytotoxic and prooxidative. Here we investigated biological effects of bicyclic seleno-hydantoin cis-7a-ethyl-5-methyl-5-phenylselanylmethyl-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione (Hid-Se), and its palladium(II) complex, trans-bis-(cis-7a-ethyl-5-methyl-5-phenylselanylmethyl-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dionato) palladium(II) chloride ((Hid-Se)2Pd) on human colon HCT-116 and breast MDA-MB-231 cancer cell lines. Hid-Se and (Hid-Se)2Pd showed prooxidative and cytotoxic character. In all performed experiments (Hid-Se)2Pd proved to be more active, i.e. this substance exerted greater prooxidative effect, cytotoxicity and influence on cell migration potential. Even though Hid-Se and (Hid-Se)2Pd enhanced migration of HCT-116 cells, very important feature of these substances is the strong antimigratory potential on metastatic MDA-MB-231 cells.
含硒和钯的化合物分别对细胞具有多种功能作用。含硒化合物通常具有抗氧化特性，而含钯（II）化合物具有细胞毒性和促氧化作用。在此，我们研究了双环硒乙内酰脲顺式-7a-乙基-5-甲基-5-苯基硒甲基-四氢-吡咯并[1,2-c]咪唑-1,3-二酮（Hid-Se）及其钯（II）配合物反式-双-（顺式-7a-乙基-5-甲基-5-苯基硒甲基-四氢-吡咯并[1,2-c]咪唑-1,3-二ionato）钯（II）氯化物（（Hid-Se）2Pd）对人结肠HCT-116和乳腺MDA-MB-231癌细胞系的生物学效应。Hid-Se和（Hid-Se）2Pd表现出促氧化和细胞毒性特征。在所有进行的实验中，（Hid-Se）2Pd被证明更具活性，即该物质具有更大的促氧化作用、细胞毒性以及对细胞迁移潜能的影响。尽管Hid-Se和（Hid-Se）2Pd增强了HCT-116细胞的迁移，但这些物质的一个非常重要的特性是对转移性MDA-MB-231细胞具有强大的抗迁移潜能。
