Liu Feng-Yu, Ma Lei, Huo Li-Shuang, Cao Yan-Xiang, Yang Da-Long, Wang Hui, Yang Si-Dong, Ding Wen-Yuan
Department of Spinal Surgery, The Third Hospital of Hebei Medical University Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang Department of Orthopaedics, Chinese PLA General Hospital, Beijing Hebei Provincial Key Laboratory of Orthopedic Biomechanics, Shijiazhuang, China.
Medicine (Baltimore). 2017 Feb;96(5):e6026. doi: 10.1097/MD.0000000000006026.
Both the mini-plate fixation and suture suspensory fixation techniques are extensively applied in cervical laminoplasty, but which technique is superior has not been ascertained. The purpose of this meta-analysis is to compare the results between mini-plate fixation and suture suspensory fixation in cervical laminoplasty for the patients with multilevel cervical compressive myelopathy.
PubMed, Embase, the Cochrane library, CNKI, and WANFANG were searched for studies that compared mini-plate fixation and suture suspensory fixation in cervical laminoplasty up to November 1, 2016. We calculated odds ratio (OR) with 95% confidence interval (CI) for dichotomous outcomes and mean difference (MD) with 95% CI for continuous outcomes. Review Manager 5.3 was used for the statistical analyses.
A total of 25 studies, involving 1603 participants, were included in this review. The results of this meta-analysis indicated that there were statistically significant differences in postoperative Japanese Orthopedic Association (JOA) scores (MD = 0.67, 95% CI: 0.34-0.99, P < 0.001), JOA scores improvement rate (MD = 4.00, 95% CI: 2.51-5.50, P < 0.001), postoperative Visual Analogue Score (VAS) (MD = -0.81, 95% CI: -1.36 to -0.26, P = 0.004), postoperative range of motion (ROM) (MD = 4.15, 95% CI: 2.06-6.23, P < 0.001), postoperative cervical lordosis (MD = 3.1, 95% CI: 2.02-4.18, P < 0.001), postoperative anteroposterior diameter of the spinal canal (MD = 1.53, 95% CI: 0.11-2.95, P = 0.03), postoperative open angle (MD = 1.93, 95% CI: 0.14-3.71, P = 0.03), postoperative cross-sectional area of the spinal canal (MD = 37.10, 95% CI: 26.92-47.29, P < 0.001), axial symptoms (OR = 0.28, 95% CI: 0.20-0.37, P < 0.001), operation time (MD = 4.46, 95% CI: 0.74-8.19, P = 0.02), and blood loss (MD = 9.24, 95% CI: 6.86-11.62, P < 0.001). However, there was no statistically significant difference in C5 palsy (OR = 0.82, 95% CI: 0.37-1.84, P = 0.63).
As compared with suture suspensory fixation, mini-plate fixation in cervical laminoplasty appears to achieve better clinical and radiographic outcomes with fewer surgical complications. However, mini-plate fixation is associated with bigger surgical trauma. This conclusion should be interpreted cautiously and more high-quality, randomized controlled trials are needed in the future.
微型钢板固定技术和缝线悬吊固定技术在颈椎椎板成形术中均有广泛应用,但哪种技术更具优势尚未明确。本荟萃分析的目的是比较微型钢板固定与缝线悬吊固定在多节段颈椎压迫性脊髓病患者颈椎椎板成形术中的效果。
检索了PubMed、Embase、Cochrane图书馆、中国知网和万方数据库,查找截至2016年11月1日比较微型钢板固定与缝线悬吊固定在颈椎椎板成形术中应用的研究。对于二分变量结果,计算比值比(OR)及95%置信区间(CI);对于连续变量结果,计算均值差(MD)及95%CI。采用Review Manager 5.3进行统计分析。
本综述共纳入25项研究,涉及1603名参与者。该荟萃分析结果表明,术后日本骨科协会(JOA)评分(MD = 0.67,95%CI:0.34 - 0.99,P < 0.001)、JOA评分改善率(MD = 4.00,95%CI:2.51 - 5.50,P < 0.001)、术后视觉模拟评分(VAS)(MD = -0.81,95%CI:-1.36至-0.26,P = 0.004)、术后活动范围(ROM)(MD = 4.15,95%CI:2.06 - 6.23,P < 0.001)、术后颈椎前凸(MD = 3.1,95%CI:2.02 - 4.18,P < 0.001)、术后椎管前后径(MD = 1.53,95%CI:0.11 - 2.95,P = 0.03)、术后开口角度(MD = 1.93,95%CI:0.14 - 3.71,P = 0.03)、术后椎管横截面积(MD = 37.10,95%CI:26.92 - 47.29,P < 0.001)、轴性症状(OR = 0.28,95%CI:0.20 - 0.37,P <
0.001)、手术时间(MD = 4.46,95%CI:0.74 - 8.19,P = 0.02)和失血量(MD = 9.24,95%CI:6.86 - 11.62,P < 0.001)方面存在统计学显著差异。然而,在C5麻痹方面无统计学显著差异(OR = 0.82,95%CI:0.37 - 1.84,P = 0.63)。
与缝线悬吊固定相比,颈椎椎板成形术中微型钢板固定似乎能获得更好的临床和影像学效果,手术并发症更少。然而,微型钢板固定与更大的手术创伤相关。该结论应谨慎解读,未来需要更多高质量的随机对照试验。