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下鼻甲骨折外移术和下鼻甲黏膜下切除术治疗儿童慢性鼻充血后的鼻腔鼻窦生活质量

Sinonasal Quality of Life in Children After Outfracture of Inferior Turbinates and Submucous Inferior Turbinoplasty for Chronic Nasal Congestion.

作者信息

Manzi Brian, Sykes Kevin J, Wei Julie L

机构信息

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Central Florida College of Medicine, Orlando.

Department of Otolaryngology-Head and Neck Surgery, University of Kansas School of Medicine, Kansas City.

出版信息

JAMA Otolaryngol Head Neck Surg. 2017 May 1;143(5):452-457. doi: 10.1001/jamaoto.2016.3889.

Abstract

IMPORTANCE

Chronic nasal congestion often persists in children despite empirical treatment using intranasal corticosteroids, systemic antihistamines, and/or leukotriene receptor antagonists. Symptoms are often reported even with negative results of skin or blood allergy testing. Inferior turbinoplasty has been effective in adults and children, but outfracture of inferior turbinates in children is rarely reported, as is use of validated quality-of-life measures to quantify improvements after intervention. Effective use of these 2 procedures for treating chronic nasal congestion may reduce the need for medication and improve sinonasal quality of life.

OBJECTIVE

To quantify changes in sinonasal quality of life for children after outfracture of inferior turbinates and concomitant submucous microdebrider inferior turbinoplasty for chronic nasal congestion.

DESIGN, SETTING, AND PARTICIPANTS: A case series with planned data collection was conducted in an ambulatory pediatric otolaryngology clinic among 43 patients with chronic nasal congestion who underwent surgical intervention between January 1, 2014, and May 31, 2015.

EXPOSURES

Microdebrider submucous inferior turbinoplasty (without bony resection) and outfracture of inferior turbinates.

MAIN OUTCOMES AND MEASURES

Demographics and medication use before and after the procedure were reviewed. Scores on the Sinus and Nasal Quality of Life Survey (SN-5) and quality-of-life scores were collected at baseline, 4 to 6 weeks after the procedure, and more than 6 months after the procedure.

RESULTS

Among the 43 patients (14 girls and 29 boys; mean age, 11.2 years [range, 4.8-17.6 years]), every domain showed significant improvements in scores on the Sinus and Nasal Quality of Life Survey and quality-of-life scores 1 to 2 months after the proecdure: sinus infection (-2.55; 95% CI, 1.85-3.26), nasal obstruction (-3.51; 95% CI, 2.88-4.14), allergy symptoms (-2.14; 95% CI, 1.43-2.86), emotional distress (-2.37; 95% CI, 1.68-3.06), activity limitation (-1.70; 95% CI, 1.14-2.25), and overall quality of life (3.72; 95% CI, 2.95-4.48). At long-term follow-up, improvement was maintained in all categories. Significant improvements in SN-5 and quality-of-life scores correlated with proportional decreased reporting of snoring after the procedure (33 [77%] vs 1 [2%]; absolute reduction, 75%; 95% CI, 62%-88%), as well as nasal congestion (41 [95%] vs 1 [2%]; absolute reduction, 93% ; 95% CI, 85%-100%), and rhinorrhea (44 [41%] vs 1 [2%]; absolute reduction, 42%; 95% CI, 27%-57%). The proportion reporting use of intranasal corticosteroids (25 [58%] vs 2 [5%]; absolute reduction, 50%; 95% CI, 39%-71%), antihistamines (27 [63%] vs 1 [2%]; absolute reduction, 61%; 95% CI, 46%-75%), and leukotriene receptor antagonists (13 [30%] vs 0; absolute reduction, 30%; 95% CI, 16%-44%) also decreased.

CONCLUSIONS AND RELEVANCE

Concomitant outfracture and submucous microdebrider inferior turbinoplasty improves quality of life in children with chronic nasal congestion and can reduce use of daily medication.

摘要

重要性

尽管使用鼻内皮质类固醇、全身性抗组胺药和/或白三烯受体拮抗剂进行了经验性治疗,但慢性鼻充血在儿童中常常持续存在。即使皮肤或血液过敏测试结果为阴性,症状也经常被报告。下鼻甲成形术在成人和儿童中均有效,但儿童下鼻甲骨折很少被报道,使用经过验证的生活质量测量方法来量化干预后改善情况的也很少。有效使用这两种治疗慢性鼻充血的方法可能会减少药物需求并改善鼻窦生活质量。

目的

量化下鼻甲骨折及同期使用黏膜下微型切割器行下鼻甲成形术治疗慢性鼻充血后儿童鼻窦生活质量的变化。

设计、地点和参与者:在一家门诊儿科耳鼻喉科诊所进行了一项有计划数据收集的病例系列研究,研究对象为2014年1月1日至2015年5月31日期间接受手术干预的43例慢性鼻充血患儿。

暴露因素

黏膜下微型切割器下鼻甲成形术(不进行骨质切除)和下鼻甲骨折。

主要结局和测量指标

回顾手术前后的人口统计学资料和药物使用情况。在基线、术后4至6周以及术后6个月以上收集鼻窦和鼻腔生活质量调查问卷(SN - 5)评分及生活质量评分。

结果

在43例患者(14例女孩和29例男孩;平均年龄11.2岁[范围4.8 - 17.6岁])中,术后1至2个月,鼻窦和鼻腔生活质量调查问卷的各个领域以及生活质量评分均有显著改善:鼻窦感染(-2.55;95%置信区间,1.85 - 3.26)、鼻塞(-3.51;95%置信区间,2.88 - 4.14)、过敏症状(-2.14;95%置信区间,1.43 - 2.86)、情绪困扰(-2.37;95%置信区间,1.68 - 3.06)、活动受限(-1.70;95%置信区间,1.14 - 2.25)以及总体生活质量(3.72;95%置信区间,2.95 - 4.48)。在长期随访中,所有类别均保持改善。SN - 5和生活质量评分的显著改善与术后打鼾报告比例的成比例下降相关(33例[77%]对1例[2%];绝对下降率75%;95%置信区间,62% - 88%),以及鼻塞(41例[95%]对1例[2%];绝对下降率93%;95%置信区间,85% - 100%)和鼻漏(44例[41%]对1例[2%];绝对下降率42%;95%置信区间,27% - 57%)。报告使用鼻内皮质类固醇(25例[58%]对2例[5%];绝对下降率50%;95%置信区间,39% - 71%)、抗组胺药(27例[63%]对1例[2%];绝对下降率61%;95%置信区间,46% - 75%)和白三烯受体拮抗剂(13例[30%]对0例;绝对下降率30%;95%置信区间,16% - 44%)的比例也下降。

结论及相关性

同期下鼻甲骨折和黏膜下微型切割器下鼻甲成形术可改善慢性鼻充血患儿的生活质量,并可减少日常药物使用。

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