Kennedy Richard E, Sawyer Patricia, Williams Courtney P, Lo Alexander X, Ritchie Christine S, Roth David L, Allman Richard M, Brown Cynthia J
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Comprehensive Center for Healthy Aging, Birmingham, Alabama.
J Am Geriatr Soc. 2017 Apr;65(4):833-838. doi: 10.1111/jgs.14738. Epub 2017 Feb 2.
To examine 6-month change in life-space mobility as a predictor of subsequent 6-month mortality in community-dwelling older adults.
Prospective cohort study.
Community-dwelling older adults from five Alabama counties in the University of Alabama at Birmingham (UAB) Study of Aging.
A random sample of 1,000 Medicare beneficiaries, stratified according to sex, race, and rural or urban residence, recruited between November 1999 and February 2001, followed by a telephone interview every 6 months for the subsequent 8.5 years.
Mortality data were determined from informant contacts and confirmed using the National Death Index and Social Security Death Index. Life-space was measured at each interview using the UAB Life-Space Assessment, a validated instrument for assessing community mobility. Eleven thousand eight hundred seventeen 6-month life-space change scores were calculated over 8.5 years of follow-up. Generalized linear mixed models were used to test predictors of mortality at subsequent 6-month intervals.
Three hundred fifty-four deaths occurred within 6 months of two sequential life-space assessments. Controlling for age, sex, race, rural or urban residence, and comorbidity, life-space score and life-space decline over the preceding 6-month interval predicted mortality. A 10-point decrease in life-space resulted in a 72% increase in odds of dying over the subsequent 6 months (odds ratio = 1.723, P < .001).
Life-space score at the beginning of a 6-month interval and change in life-space over 6 months were each associated with significant differences in subsequent 6-month mortality. Life-space assessment may assist clinicians in identifying older adults at risk of short-term mortality.
研究生活空间活动能力在6个月内的变化,以此作为社区居住老年人后续6个月死亡率的预测指标。
前瞻性队列研究。
阿拉巴马大学伯明翰分校(UAB)衰老研究中来自阿拉巴马州5个县的社区居住老年人。
1999年11月至2001年2月招募的1000名医疗保险受益人的随机样本,按性别、种族和城乡居住地分层,随后在接下来的8.5年中每6个月进行一次电话访谈。
通过与信息提供者联系确定死亡数据,并使用国家死亡指数和社会保障死亡指数进行确认。每次访谈时使用UAB生活空间评估量表测量生活空间,这是一种经过验证的评估社区活动能力的工具。在8.5年的随访中计算了11817个6个月生活空间变化分数。使用广义线性混合模型测试后续6个月间隔内死亡率的预测指标。
在连续两次生活空间评估的6个月内发生了354例死亡。在控制年龄、性别、种族、城乡居住地和合并症的情况下,前6个月间隔内的生活空间分数和生活空间下降情况可预测死亡率。生活空间下降10分导致后续6个月内死亡几率增加72%(优势比=1.723,P<.001)。
6个月间隔开始时的生活空间分数以及6个月内生活空间的变化均与后续6个月死亡率的显著差异相关。生活空间评估可能有助于临床医生识别有短期死亡风险的老年人。