INSERM U 1103, Génétique Reproduction et Développement (GReD), F-63170 Aubière, France; Université Clermont Auvergne, GReD, F-63000 Clermont-Ferrand, F-63170 Aubière, France; CNRS, UMR 6293, GReD, F-63170 Aubière, France; Centre de Recherche en Nutrition Humaine d'Auvergne, F-63000 Clermont-Ferrand, France.
INSERM U 1103, Génétique Reproduction et Développement (GReD), F-63170 Aubière, France; Université Clermont Auvergne, GReD, F-63000 Clermont-Ferrand, F-63170 Aubière, France; CNRS, UMR 6293, GReD, F-63170 Aubière, France; Centre de Recherche en Nutrition Humaine d'Auvergne, F-63000 Clermont-Ferrand, France.
Mol Aspects Med. 2017 Aug;56:2-9. doi: 10.1016/j.mam.2017.01.006. Epub 2017 Jan 30.
Primary bile acids are synthetized from cholesterol within the liver and then transformed by the bacteria in the intestine to secondary bile acids. In addition to their involvement in digestion and fat solubilization, bile acids also act as signaling molecules. Several receptors are sensors of bile acids. Among these receptors, this review focuses on the nuclear receptor FXRα and the G-protein-coupled receptor TGR5. This review briefly presents the potential links between bile acids and cancers that are discussed in more details in the other articles of this special issue of Molecular Aspects of Medicine focused on "Bile acids, roles in integrative physiology and pathophysiology".
初级胆汁酸在肝脏内由胆固醇合成，然后在肠道细菌的作用下转化为次级胆汁酸。除了参与消化和脂肪溶解外，胆汁酸还作为信号分子发挥作用。几种受体是胆汁酸的传感器。在这些受体中，本综述重点介绍了核受体 FXRα 和 G 蛋白偶联受体 TGR5。本综述简要介绍了胆汁酸与癌症之间的潜在联系，这在本期《分子医学视角》特刊的其他文章中进行了更详细的讨论，主题为“胆汁酸在整合生理学和病理生理学中的作用”。
