胆汁酸对神经功能和疾病的影响。
Effects of bile acids on neurological function and disease.
作者信息
McMillin Matthew, DeMorrow Sharon
机构信息
Texas A&M University Health Science Center, College of Medicine, Department of Internal Medicine, Temple, Texas, USA; and.
Central Texas Veterans Health Care System, Temple, Texas, USA.
出版信息
FASEB J. 2016 Nov;30(11):3658-3668. doi: 10.1096/fj.201600275R. Epub 2016 Jul 28.
Abstract
Bile acids are synthesized from cholesterol and are known to be involved with the emulsification and digestion of dietary lipids and fat-soluble vitamins. Outside of this role, bile acids can act as cell signaling effectors through binding and activating receptors on both the cell membrane and nucleus. Numerous reports have investigated these signaling pathways in conditions where the liver is damaged. More recently, effort has been made to investigate the role of bile acids in diseases outside of those associated with liver damage. This review summarizes recent findings on the influences that bile acids can exert in normal neurological function and their contribution to diseases of the nervous system, with the intent of highlighting the role of these metabolites as potential players in neurological disorders.-McMillin, M., DeMorrow, S. Effects of bile acids on neurological function and disease.
摘要
胆汁酸由胆固醇合成，已知其参与膳食脂质和脂溶性维生素的乳化与消化。除此之外，胆汁酸可通过与细胞膜和细胞核上的受体结合并激活这些受体，从而作为细胞信号效应器发挥作用。许多报告研究了肝脏受损情况下的这些信号通路。最近，人们努力研究胆汁酸在与肝损伤无关的疾病中的作用。这篇综述总结了关于胆汁酸对正常神经功能的影响及其对神经系统疾病的贡献的最新发现，旨在强调这些代谢产物作为神经疾病潜在参与者的作用。——麦克米林，M.，德莫罗，S. 胆汁酸对神经功能和疾病的影响
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