Tao Tao, Zhang Ying-Hui, Xue Sheng-Li, Wu De-Pei, Chen Feng
Department of Hematology, the Xinghai Hospital of Suzhou Industrial Park, China.
Intern Med. 2017;56(3):347-351. doi: 10.2169/internalmedicine.56.7201. Epub 2017 Feb 1.
A 23-year-old man who had previously undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT) for severe aplastic anemia was diagnosed with invasive laryngeal-tracheobronchial-pulmonary aspergillosis after presenting with a persistent dry cough at six months post-transplantation based on the findings of laryngoscopy and fiberoptic bronchoscopy. A fiberoptic bronchoscope was used to remove the obstructive material from the patient's airway and posaconazole plus caspofungin were administered to successfully to treat the patient. Our report suggests that laryngoscopy and fiberoptic bronchoscopy should be considered as alternative approaches to the diagnosis and treatment of allo-HSCT recipients with persistent respiratory symptoms when invasive laryngeal aspergillosis and invasive tracheobronchial aspergillosis are suspected.
一名23岁男性，此前因严重再生障碍性贫血接受了异基因造血干细胞移植（allo-HSCT），在移植后6个月出现持续干咳，根据喉镜检查和纤维支气管镜检查结果，被诊断为侵袭性喉气管支气管肺曲霉病。使用纤维支气管镜清除患者气道内的阻塞物，并给予泊沙康唑加卡泊芬净成功治疗该患者。我们的报告表明，当怀疑侵袭性喉曲霉病和侵袭性气管支气管曲霉病时，喉镜检查和纤维支气管镜检查应被视为诊断和治疗有持续呼吸道症状的allo-HSCT受者的替代方法。
