Kanai Tomohiro, Samejima Yumiko, Noda Yoshimi, Kim Sung-Ho, Tamura Kanako, Umakoshi Taisei, Shimizu Kazunori, Kashiwa Yozo, Morishita Hiroshi, Ueda Kayo, Kawahara Kunimitsu, Yaguchi Takashi, Matsuoka Hiroto
Department of Pulmonary and Critical Care Medicine, Osaka Habikino Medical Center, Japan.
Department of Pathology, Osaka Habikino Medical Center, Japan.
Intern Med. 2020 May 1;59(9):1189-1194. doi: 10.2169/internalmedicine.3827-19. Epub 2020 Feb 1.
Invasive tracheobronchial aspergillosis (ITBA) complicated by nontuberculous mycobacteria (NTM) is rare. An 88-year-old man was admitted for hemoptysis. Bronchoscopy revealed bronchial ulcers, and a tissue biopsy showed Aspergillus fumigatus. He was diagnosed with ITBA, which improved with voriconazole. During treatment, infiltrative shadows appeared in his lungs, and bronchoscopy was performed once again. A non-necrotic epithelioid granuloma and Mycobacterium intracellulare were detected in the biopsy specimen. He was diagnosed with NTM disease. It is important to note that tracheobronchial ulcers may cause hemoptysis and to identify the etiology and treat it appropriately when multiple bacteria are found.
侵袭性气管支气管曲霉病(ITBA)合并非结核分枝杆菌(NTM)较为罕见。一名88岁男性因咯血入院。支气管镜检查发现支气管溃疡,组织活检显示烟曲霉。他被诊断为ITBA,使用伏立康唑治疗后病情好转。治疗期间,其肺部出现浸润性阴影,遂再次进行支气管镜检查。活检标本中检测到非坏死性上皮样肉芽肿和细胞内分枝杆菌。他被诊断为NTM病。需要注意的是,气管支气管溃疡可能导致咯血,当发现多种细菌时,应确定病因并进行适当治疗。