Africa Charlene Wilma Joyce, Abrantes Pedro Miguel Dos Santos
Microbial Endogenous Infections (MEnIS) Research Laboratories, Department of Medical Biosciences, University of the Western Cape, Bellville, South Africa.
F1000Res. 2016 Dec 8;5:2832. doi: 10.12688/f1000research.10327.2. eCollection 2016.
: infections are responsible for increased morbidity and mortality rates in at-risk patients, especially in developing countries where there is limited access to antifungal drugs and a high burden of HIV co-infection. This study aimed to identify antifungal drug resistance patterns within the subcontinent of Africa. : A literature search was conducted on published studies that employed antifungal susceptibility testing on clinical isolates from sub-Saharan African countries using Pubmed and Google Scholar. : A total of 21 studies from 8 countries constituted this review. Only studies conducted in sub-Saharan Africa and employing antifungal drug susceptibility testing were included. Regional differences in species prevalence and resistance patterns were identified. : The outcomes of this review highlight the need for a revision of antifungal therapy guidelines in regions most affected by drug resistance. Better controls in antimicrobial drug distribution and the implementation of regional antimicrobial susceptibility surveillance programmes are required in order to reduce the high drug resistance levels seen to be emerging in sub-Saharan Africa.
感染是导致高危患者发病率和死亡率上升的原因，尤其是在那些获得抗真菌药物的机会有限且艾滋病毒合并感染负担沉重的发展中国家。本研究旨在确定非洲次大陆内的抗真菌药物耐药模式。对已发表的研究进行了文献检索，这些研究使用PubMed和谷歌学术对来自撒哈拉以南非洲国家的临床分离株进行了抗真菌药敏试验。本综述共纳入了来自8个国家的21项研究。仅纳入在撒哈拉以南非洲进行且采用抗真菌药物药敏试验的研究。确定了物种流行率和耐药模式的区域差异。本综述的结果突出表明，在受耐药性影响最严重的地区需要修订抗真菌治疗指南。为了降低在撒哈拉以南非洲出现的高耐药水平，需要更好地控制抗菌药物的分发并实施区域抗菌药敏监测计划。
