Fucíková E, Kimlová I, Kuzela L, Vísek V
Vnitr Lek. 1989 Sep;35(9):885-9.
The authors assessed the concentration of primary bile acids in patients with liver diseases, diseases of the gallbladder and biliary pathways, with affections of the pancreas and in a control group. Primary bile acids and their conjugated derivatives were assessed by radioimmunoanalysis from the patients' serum, using radiodiagnostic sets of Farmos Co. Finland. The range of the assessed concentrations was 0.15-15 mumol/l. The total number of examined subjects was 56, blood specimens for estimation of bile acids were collected in the morning after 12 hours fasting. From the investigation ensues that primary bile acids were elevated in diseases of the hepatobiliary tract; in diseases of the gallbladder and biliary pathways an increased ratio of glycocholic to glycochenodeoxycholic acid was found. Elevated concentrations of the two investigated primary bile acids were also found in subjects with tumorous diseases. Consistent with the result of other authors, it is obvious that estimation of bile acids is a sensitive liver function test.
作者评估了患有肝脏疾病、胆囊和胆道疾病、胰腺疾病患者以及对照组中初级胆汁酸的浓度。使用芬兰Farmos公司的放射诊断试剂盒，通过放射免疫分析对患者血清中的初级胆汁酸及其共轭衍生物进行评估。评估的浓度范围为0.15 - 15微摩尔/升。检查的受试者总数为56名，在禁食12小时后的早晨采集用于胆汁酸评估的血液样本。调查结果显示，初级胆汁酸在肝胆道疾病中升高；在胆囊和胆道疾病中，发现甘氨胆酸与甘氨鹅脱氧胆酸的比例增加。在患有肿瘤疾病的受试者中也发现了两种被研究的初级胆汁酸浓度升高。与其他作者的结果一致，很明显胆汁酸评估是一种敏感的肝功能测试。
