Pagani A, Pranzo A, Galante T
Minerva Med. 1984 Jan 28;75(3-4):99-107.
Determination of serum bile acids has long been regarded as the most sensitive indicator of liver function. An assessment was made of the clinical applicability of RIA evaluation of two of these acids, cholylglycine (CG) and sulpholithochocholyglycine (SLGG), on an empty stomach and 2hr after a cholecystokinetic meal in 109 liver patients ans 20 controls. After the meal test, both acids proved more sensitive than the usual liver function indices. Different mean values were observed for different diseases. They were in good correlation with the extent of histological damage. Values were highest in obstructive icterus, cirrhosis and neoplasia of the liver, fairly highly high in steatofibrosis, ACH and PCH, and normal in viral hepatitis in the course of resolution, aspecific reactive hepatitis, and steatosis. The meal test thus proved a good indicator of liver disease. Its wider use is to be hoped for in order that its limits and applications may be better understood.
血清胆汁酸的测定长期以来一直被视为肝功能最敏感的指标。对109例肝病患者和20例对照者空腹及胆囊收缩素餐后2小时，采用放射免疫分析法评估其中两种胆汁酸，即胆酰甘氨酸（CG）和磺石胆酰甘氨酸（SLGG）的临床适用性。餐后试验显示，这两种胆汁酸均比常用的肝功能指标更为敏感。不同疾病观察到不同的均值，且与组织学损伤程度密切相关。在梗阻性黄疸、肝硬化和肝脏肿瘤中值最高，在脂肪纤维变性、急性肝萎缩和慢性迁延性肝炎中相当高，而在病毒性肝炎恢复期、非特异性反应性肝炎和脂肪肝中值正常。因此，餐后试验证明是肝病的良好指标。希望能更广泛地使用该试验，以便更好地了解其局限性和应用情况。
