[硫酸鱼精蛋白对四氧嘧啶致糖尿病作用的强化]
[Intensification of the diabetogenic effect of alloxan by protamine sulfate].
作者信息
Kudriashov B A, Ul'ianov A M, Tarasov Iu A
出版信息
Vopr Med Khim. 1989 Jul-Aug;35(4):128-31.
PMID:2815670
Abstract
Administration of protamine sulfate into circulation was shown to increase the diabetogenic effect of alloxan. Protamine sulfate bound endogenous heparin, as a result of which the diabetogenic factor caused more severe forms of experimental diabetes. At the same time, the diabetogenic factor exhibited distinctly higher activity during the heparin deficiency developed.
摘要
将硫酸鱼精蛋白注入循环系统后，发现其会增强四氧嘧啶的致糖尿病作用。硫酸鱼精蛋白与内源性肝素结合，结果导致致糖尿病因子引发更严重形式的实验性糖尿病。同时，在出现肝素缺乏的情况下，致糖尿病因子表现出明显更高的活性。
Zotero 插件