Li Yan, Sanchez Connie, Gulinello Maria
Lundbeck Research USA, Paramus, New Jersey (Drs Li and Sanchez); Behavioral Core Facility, Neuroscience Dept., Albert Einstein College of Medicine (Dr Gulinello).
Int J Neuropsychopharmacol. 2017 Jun 1;20(6):510-515. doi: 10.1093/ijnp/pyx004.
Cognitive dysfunction is among the key symptoms of major depressive disorder and can be affected by antidepressants. Cognitive decline also occurs in normal aging. The effects of different antidepressants on affective and cognitive domains in older subjects are seldom assessed simultaneously.
Healthy middle-aged female mice received vehicle or antidepressant (vortioxetine, vilazodone, duloxetine, or fluoxetine) at therapeutic doses. After 1 month treatment, mice were accessed for visuospatial memory and depression-like behavior. A separate cohort of mice received 3 months of treatment and was test for recognition memory and depression-like behavior.
After 1 month treatment, vortioxetine improved visuospatial memory and reduced depression-like behavior. Vilazodone reduced depression-like behavior. Duloxetine and fluoxetine were ineffective in both tests. After 3 months treatment, vortioxetine reduced depression-like behavior without affecting recognition memory, while fluoxetine impaired recognition memory. Duloxetine and vilazodone had no effect in both tests.
Different antidepressants have distinct effects in middle-aged female mice.
认知功能障碍是重度抑郁症的关键症状之一，且可能受到抗抑郁药的影响。认知衰退在正常衰老过程中也会出现。不同抗抑郁药对老年受试者情感和认知领域的影响很少同时进行评估。
健康的中年雌性小鼠接受治疗剂量的赋形剂或抗抑郁药（伏硫西汀、维拉唑酮、度洛西汀或氟西汀）。治疗1个月后，对小鼠进行视觉空间记忆和抑郁样行为评估。另一组小鼠接受3个月的治疗，并进行识别记忆和抑郁样行为测试。
治疗1个月后，伏硫西汀改善了视觉空间记忆并减少了抑郁样行为。维拉唑酮减少了抑郁样行为。度洛西汀和氟西汀在两项测试中均无效。治疗3个月后，伏硫西汀减少了抑郁样行为，而未影响识别记忆，而氟西汀损害了识别记忆。度洛西汀和维拉唑酮在两项测试中均无作用。
不同的抗抑郁药在中年雌性小鼠中具有不同的作用。
