Cardiac cell-derived exosomes: changing face of regenerative biology.
作者信息
Kishore Raj, Khan Mohsin
机构信息
Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA
出版信息
Eur Heart J. 2017 Jan 14;38(3):212-215. doi: 10.1093/eurheartj/ehw324.
Abstract
摘要
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本文引用的文献
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Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction.心脏球来源细胞分泌的细胞外囊泡可减少疤痕形成、减弱不良重构、改善急性和慢性猪心肌梗死的功能。
Eur Heart J. 2017 Jan 14;38(3):201-211. doi: 10.1093/eurheartj/ehw240.
2
More Than Tiny Sacks: Stem Cell Exosomes as Cell-Free Modality for Cardiac Repair.不止是微小囊泡：干细胞外泌体作为心脏修复的无细胞治疗方式
Circ Res. 2016 Jan 22;118(2):330-43. doi: 10.1161/CIRCRESAHA.115.307654.
3
Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction.胚胎干细胞衍生的外泌体可促进内源性修复机制，并增强心肌梗死后的心脏功能。
Circ Res. 2015 Jun 19;117(1):52-64. doi: 10.1161/CIRCRESAHA.117.305990. Epub 2015 Apr 22.
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Allogeneic cardiospheres delivered via percutaneous transendocardial injection increase viable myocardium, decrease scar size, and attenuate cardiac dilatation in porcine ischemic cardiomyopathy.通过经皮心内膜注射递送的同种异体心肌球可增加猪缺血性心肌病的存活心肌、减小瘢痕大小并减轻心脏扩张。
PLoS One. 2014 Dec 2;9(12):e113805. doi: 10.1371/journal.pone.0113805. eCollection 2014.
5
Sustained delivery of insulin-like growth factor-1/hepatocyte growth factor stimulates endogenous cardiac repair in the chronic infarcted pig heart.持续递送胰岛素样生长因子-1/肝细胞生长因子可刺激慢性梗死猪心脏中的内源性心脏修复。
J Cardiovasc Transl Res. 2014 Mar;7(2):232-41. doi: 10.1007/s12265-013-9518-4. Epub 2014 Jan 7.
6
7
Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury.间充质干细胞衍生的外泌体可提高三磷酸腺苷（ATP）水平，降低氧化应激，并激活磷脂酰肌醇-3-激酶/蛋白激酶B（PI3K/Akt）信号通路，从而增强心肌活力，预防心肌缺血/再灌注损伤后的不良重塑。
Stem Cell Res. 2013 May;10(3):301-12. doi: 10.1016/j.scr.2013.01.002. Epub 2013 Jan 14.
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Effects of intracoronary CD34+ stem cell transplantation in nonischemic dilated cardiomyopathy patients: 5-year follow-up.经冠状动脉内 CD34+ 干细胞移植治疗非缺血性扩张型心肌病患者：5 年随访结果。
Circ Res. 2013 Jan 4;112(1):165-73. doi: 10.1161/CIRCRESAHA.112.276519. Epub 2012 Oct 12.
9
Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial.冠状动脉心脏球源性细胞治疗心肌梗死后的心脏再生（CADUCEUS）：一项前瞻性、随机 1 期试验。
Lancet. 2012 Mar 10;379(9819):895-904. doi: 10.1016/S0140-6736(12)60195-0. Epub 2012 Feb 14.
10
Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial.缺血性心肌病患者的心脏干细胞（SCIPIO）：一项随机 1 期试验的初步结果。
Lancet. 2011 Nov 26;378(9806):1847-57. doi: 10.1016/S0140-6736(11)61590-0. Epub 2011 Nov 14.
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