发作性睡病：评估、治疗以及社会和经济方面

Hypersomnia: Evaluation, Treatment, and Social and Economic Aspects.

作者信息

Saini Prabhjyot, Rye David B

机构信息

Department of Neurology, Emory University School of Medicine, 12 Executive Park Drive Northeast, Room 426, Atlanta, GA 30329, USA.

Department of Neurology and Program in Sleep, Emory University School of Medicine, 12 Executive Park Drive Northeast, Room 427, Atlanta, GA 30329, USA.

出版信息

Sleep Med Clin. 2017 Mar;12(1):47-60. doi: 10.1016/j.jsmc.2016.10.013.

DOI:10.1016/j.jsmc.2016.10.013

PMID:28159097

Abstract

Most central disorders of hypersomnolence are conditions with poorly understood pathophysiologies, making their identification, treatment, and management challenging for sleep clinicians. The most challenging to diagnose and treat is idiopathic hypersomnia. There are no FDA-approved treatments, and off-label usage of narcolepsy treatments seldom provide benefit. Patients are largely left on their own to alleviate the compound effects of this disorder on their quality of life. This review covers the major points regarding clinical features and diagnosis of idiopathic hypersomnia, reviews current evidence supporting the available treatment options, and discusses the psychosocial impact and effects of idiopathic hypersomnia.

摘要

大多数中枢性过度嗜睡障碍的病理生理学机制尚不清楚，这使得睡眠临床医生对其进行识别、治疗和管理具有挑战性。最难诊断和治疗的是特发性嗜睡症。目前尚无美国食品药品监督管理局（FDA）批准的治疗方法，使用发作性睡病治疗药物的非标签用药很少能带来益处。患者很大程度上只能自行缓解这种疾病对其生活质量的复合影响。本综述涵盖了特发性嗜睡症的临床特征和诊断要点，回顾了支持现有治疗选择的当前证据，并讨论了特发性嗜睡症的心理社会影响。