Feng Jing, Wen Yixue, Zhang Zhen, Zhang Ye
Department of Breast Center, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, People's Republic of China.
Department of Neurosurgery, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, People's Republic of China.
Sci Rep. 2024 Jul 31;14(1):17746. doi: 10.1038/s41598-024-68856-z.
Globally, breast cancer continues to be the leading cause of cancer-related incidence and mortality among females. Research has shown that sleep patterns significantly influence tumor onset and progression. In this research, the association was examined through the application of a two-sample Mendelian randomization (MR) approach. For the analysis of seven sleep patterns, genetic tools were sourced from both the UK Biobank and 23andMe, including morning/evening person (chronotype) n = 177,604, morning person (chronotype) n = 248,094, daytime dozing/sleepiness n = 193,472, getting up in the morning n = 193,717, and sleeplessness n = 193,987; sleep duration n = 192,810; and nap during the day n = 166,853. The Breast Cancer Association Consortium (BCAC) supplied genome-wide association studies (GWAS) data, including 133,384 breast cancer cases and 113,789 controls, alongside subtype-specific data with 106,278 cases and 91,477 controls. We discovered that chronotype encompasses both morning and evening types contributes to the risk of overall breast cancer. While daytime dozing and morning person (chronotype) are linked to a lower risk of breast cancer in general, In subtype-specific analyses, morning person (chronotype) was negatively associated with luminal B, HER2-negative-like, and daytime dozing was negatively correlated with luminal A-like, luminal B-like, and HER2-enriched-like. The study corroborates that chronotype is a danger element for breast cancer, aligning with previous observational findings. The association between being a morning person (chronotype) or having daytime dozing and a decreased risk of breast cancer underscores the significance of sleep patterns in formulating strategies for cancer prevention.
在全球范围内，乳腺癌仍然是女性癌症相关发病率和死亡率的主要原因。研究表明，睡眠模式会显著影响肿瘤的发生和发展。在本研究中，通过应用两样本孟德尔随机化（MR）方法来检验这种关联。对于七种睡眠模式的分析，遗传工具来自英国生物银行和23andMe，包括晨型/夜型（昼夜节律类型）n = 177,604、晨型（昼夜节律类型）n = 248,094、白天打瞌睡/嗜睡n = 193,472、早晨起床n = 193,717以及失眠n = 193,987；睡眠时长n = 192,810；以及白天小睡n = 166,853。乳腺癌协会联盟（BCAC）提供了全基因组关联研究（GWAS）数据，包括133,384例乳腺癌病例和113,789例对照，以及亚型特异性数据，其中有106,278例病例和91,477例对照。我们发现，包括晨型和夜型的昼夜节律类型会增加总体乳腺癌的风险。虽然白天打瞌睡和晨型（昼夜节律类型）通常与较低的乳腺癌风险相关，但在亚型特异性分析中，晨型（昼夜节律类型）与管腔B型、HER2阴性样亚型呈负相关，白天打瞌睡与管腔A型、管腔B型和HER2富集样亚型呈负相关。该研究证实，昼夜节律类型是乳腺癌的一个危险因素，这与之前的观察结果一致。晨型（昼夜节律类型）或白天打瞌睡与降低乳腺癌风险之间的关联强调了睡眠模式在制定癌症预防策略中的重要性。
