Wais Peter E, Jahanikia Sahar, Steiner Daniel, Stark Craig E L, Gazzaley Adam
Department of Neurology & Center for Integrative Neurosciences, University of California, San Francisco, United States.
Department of Neurology & Center for Integrative Neurosciences, University of California, San Francisco, United States.
Neuroimage. 2017 Apr 1;149:178-189. doi: 10.1016/j.neuroimage.2017.01.062. Epub 2017 Jan 31.
Medial temporal lobe (MTL) function is well established as necessary for memory of facts and events. It is likely that lateral cortical regions critically guide cognitive control processes to tune in high-fidelity details that are most relevant for memory retrieval. Here, convergent results from functional and structural MRI show that retrieval of detailed episodic memory arises from lateral cortical-MTL networks, including regions of inferior frontal and angular gyrii. Results also suggest that recognition of items based on low-fidelity, generalized information, rather than memory arising from retrieval of relevant episodic details, is not associated with functional connectivity between MTL and lateral cortical regions. Additionally, individual differences in microstructural properties in white matter pathways, associated with distributed MTL-cortical networks, are positively correlated with better performance on a mnemonic discrimination task.
内侧颞叶（MTL）功能已被确认为事实和事件记忆所必需。外侧皮质区域很可能对认知控制过程起着关键的引导作用，以筛选出与记忆检索最相关的高保真细节。在这里，功能磁共振成像和结构磁共振成像的趋同结果表明，详细情景记忆的检索源自外侧皮质 - MTL网络，包括额下回和角回区域。结果还表明，基于低保真、广义信息的项目识别，而非来自相关情景细节检索的记忆，与MTL和外侧皮质区域之间的功能连接无关。此外，与分布式MTL - 皮质网络相关的白质通路微观结构特性的个体差异，与记忆辨别任务中的更好表现呈正相关。
