Yokoi Tae, Zhu Dan, Bi Hong Sheng, Jonas Jost B, Jonas Rahul A, Nagaoka Natsuko, Moriyama Muka, Yoshida Takeshi, Ohno-Matsui Kyoko
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):901-906. doi: 10.1167/iovs.16-20652.
To analyze morphologic features of segmental parapapillary diffuse choroidal atrophy (PDCA) in children.
The study group included children (age ≤15 years) with high myopia who attended the Tokyo High Myopia Clinic. Control groups comprised participants of the population-based Gobi Desert Children Eye Study (GobiDCES). Fundus photographs were examined for presence of PDCA and choroidal thickness (CT) was measured by optical coherence tomography.
The study group included 41 eyes of 21 children with PDCA (mean age: 9.4 ± 3.7 years; mean refractive error: -11.5 ± 3.1 diopters) and the GobiDCES included 1463 children (age: 11.8 ± 3.5 years). In the study group, all eyes showed an extreme and abrupt thinning of the temporal parapapillary choroid. At 2500 μm nasal to the foveola, CT was <60 μm in 31 (76%) eyes of the study group but in none (0/1463) of the GobiDCES (P < 0.001), except for one child with PDCA.
Parapapillary diffuse choroidal atrophy in children is associated with abrupt segmental thinning of the choroid in the temporal parapapillary region, in addition to the thinning of the subfoveal choroid after adjusting for refractive error and age.
分析儿童节段性视乳头旁弥漫性脉络膜萎缩（PDCA）的形态学特征。
研究组包括在东京高度近视诊所就诊的高度近视儿童（年龄≤15岁）。对照组包括基于人群的戈壁沙漠儿童眼病研究（GobiDCES）的参与者。检查眼底照片是否存在PDCA，并通过光学相干断层扫描测量脉络膜厚度（CT）。
研究组包括21名患有PDCA的儿童的41只眼（平均年龄：9.4±3.7岁；平均屈光不正：-11.5±3.1屈光度），GobiDCES包括1463名儿童（年龄：11.8±3.5岁）。在研究组中，所有眼睛均显示颞侧视乳头旁脉络膜极度且突然变薄。在黄斑中心凹鼻侧2500μm处，研究组31只眼（76%）的CT<60μm，但GobiDCES中无一例（0/1463）如此（P<0.001），除了一名患有PDCA的儿童。
儿童视乳头旁弥漫性脉络膜萎缩除了在调整屈光不正和年龄后黄斑下脉络膜变薄外，还与颞侧视乳头旁区域脉络膜的节段性突然变薄有关。
