Department of Ophthalmology, Odense University Hospital, Odense, Denmark.
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Acta Ophthalmol. 2018 Jun;96(4):371-378. doi: 10.1111/aos.13640. Epub 2018 Jan 16.
To describe the relationship between choroidal thickness (CT) and myopia in relation to physical activity (PA) in a population-based child cohort.
In a prospective study of 307 children from the CHAMPS Study Denmark, we used objective data from GT3X accelerometer worn at four periods between 2009 and 2015 to determine the amount and intensity of PA. Intensity was estimated as counts/minutes, and cut-off points were defined at four intensity levels. Eye examinations were performed in 2015 and included autorefraction in cycloplegia, axial length (AL) by biometric and fovea-centred enhanced depth imaging optical coherence tomography. By a semi-automated method, we measured the CT at 17 targets per eye representing anatomically different locations (subfoveal, 1 and 3 millimetre in each direction of fovea).
Mean age at the eye examination was 15.4 ± 0.7 years. The mean AL was 23.5 ± 0.9 mm, and the mean subfoveal CT was 369 ± 87 μm. Choroidal thickness (CT) was 331 ± 68 μm for the overall macula, 355 ± 78 μm for the 1-mm zone and 304 ± 60 μm for the 3-mm zone. All CT measurements were thinner in myopic eyes (p < 0.0001) and in boys (p < 0.05). We found no association between total PA and the CT by either mixed model analysis (p = 0.074) or linear regression by any intensity levels (p = 0.22, p = 0.15 and p = 0.43).
Among adolescents aged 14-17 years, there was no association between objective PA exposures and the CT, AL or refractive error.
描述人群基础儿童队列中脉络膜厚度（CT）与近视的关系与体力活动（PA）的关系。
在丹麦 CHAMPS 研究的一项前瞻性研究中，我们使用了 2009 年至 2015 年期间佩戴 GT3X 加速度计的 4 个时期的客观数据，以确定 PA 的数量和强度。强度估计为每分钟计数，并且在四个强度水平定义了截止点。在 2015 年进行了眼部检查，包括在睫状肌麻痹下进行自动折射，通过生物测量和黄斑中心增强深度成像光相干断层扫描测量眼轴（AL）。通过半自动方法，我们测量了每只眼睛 17 个目标的 CT，这些目标代表了解剖上不同的位置（黄斑下，黄斑 1 和 3 毫米方向）。
眼部检查时的平均年龄为 15.4±0.7 岁。平均 AL 为 23.5±0.9mm，平均黄斑下 CT 为 369±87μm。脉络膜厚度（CT）为 331±68μm 用于整个黄斑，355±78μm 用于 1mm 区，304±60μm 用于 3mm 区。所有 CT 测量值在近视眼中均较薄（p<0.0001），在男孩中也较薄（p<0.05）。我们发现混合模型分析（p=0.074）或任何强度水平的线性回归（p=0.22，p=0.15 和 p=0.43）均未发现总 PA 与 CT 之间存在关联。
在 14-17 岁的青少年中，客观 PA 暴露与 CT、AL 或屈光不正之间没有关联。
