Lipets M E, Lopatko V N
Vestn Dermatol Venerol. 1989(7):43-7.
Zaditen combined with local therapy and a rational hygienic and dietetic regimen has been administered to 158 children suffering from neurodermatitis (n = 142), eczema (n = 13), and strophulus (n = 3). The treatment has been effective in 148 (93.7%) children. Clinical remission has been achieved in 35 (22.2%) children, a considerable improvement in 87 (55.0%), and an improvement in 26 (16.5%). In 10 (6.3%) children no improvement has been observed. The improvement has been developing within the first fortnight of the treatment, but the drug has been continued for another week or two to stabilize the therapeutic effect. A follow-up of 102 children, effectively treated with zaditen, for 1-12 mos has shown relapses in 72 (70.6%) children, of these 7 relapses of medium severity and 1 severe relapse. Zaditen has been well tolerated by the children.
对158名患有神经性皮炎（n = 142）、湿疹（n = 13）和婴儿苔癣（n = 3）的儿童使用仙特明联合局部治疗以及合理的卫生和饮食方案进行治疗。148名（93.7%）儿童治疗有效。35名（22.2%）儿童实现临床缓解，87名（55.0%）有显著改善，26名（16.5%）有改善。10名（6.3%）儿童未见改善。改善在治疗的头两周内出现，但药物继续使用一到两周以稳定治疗效果。对102名接受仙特明有效治疗的儿童进行1至12个月的随访，发现72名（70.6%）儿童复发，其中7例为中度复发，1例为重度复发。儿童对仙特明耐受性良好。
