Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695, USA.
Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Adv Mater. 2017 Apr;29(13). doi: 10.1002/adma.201605803. Epub 2017 Feb 3.
A "relay drug delivery" system based on two distinct modules, which is composed of a signal transmission nanocarrier A (NC ) that can specifically induce tumor blood vessel inflammation generation and an execution biomimetic nanocarrier B (NC ) that can accumulate at the tumor site by receiving the broadcasting signals generated by NC , is developed for amplifying active tumor targeting signal and enhancing antitumor therapy.
一种基于两个不同模块的“接力式药物传递”系统，由能特异性诱导肿瘤血管炎症产生的信号转导纳米载体 A（NC）和能通过接收 NC 产生的广播信号累积在肿瘤部位的仿生执行纳米载体 B（NC）组成，用于放大主动肿瘤靶向信号并增强抗肿瘤治疗效果。
