Batrurin V A, Shchetinin E V, Arushanian E B, Manzhikova G I
Zh Vyssh Nerv Deiat Im I P Pavlova. 1989 Jul-Aug;39(4):633-9.
Prolonged repeated electric stimulation of rats striatum causes stable behavioural depression and reorganization of temporal dynamics of forced swimming. Simultaneously increases the depression index offered by us as ratio of the number of immobilization cycles shorter than 6 s to the total number of active swimming cycles. Striatectomy and amphetamine administration (1 mg/kg) uniformly change the rhythmic structure of swimming with an increase of animals general motor activity without change of the depression index. It is suggested to use striatal inactivation as a model of depression state.
对大鼠纹状体进行长时间重复电刺激会导致稳定的行为抑制以及强迫游泳时间动态的重组。同时，我们提出的抑郁指数（即短于6秒的静止周期数与主动游泳周期总数之比）会增加。纹状体切除和给予苯丙胺（1毫克/千克）会一致地改变游泳的节律结构，增加动物的总体运动活动，但不改变抑郁指数。建议将纹状体失活作为抑郁状态的一种模型。
