Aurshanian E B, Shchetinin E V
Farmakol Toksikol. 1990 May-Jun;53(3):10-3.
Amitriptyline (10 mg/kg daily for 2 weeks) produces reorganization of the rhythmic structure of forced swimming in rats with a decrease of the rhythmical index of depression. The antidepressant attenuates also steady behavioral shifts and the associated depression in the animals' behavior after discontinuation of prolonged electrostimulation of the striatal body. The electrolytic damage of the striatal body disorganizes temporary dynamics of swimming and these shifts are enhanced by the antidepressant. It is supposed that the specific action of amitriptyline depends on modification of pacemaker striatal function.
阿米替林（每日10毫克/千克，持续2周）可使大鼠强迫游泳的节律结构发生重组，抑郁节律指数降低。这种抗抑郁药还可减轻纹状体长期电刺激停止后动物行为中稳定的行为变化及相关抑郁。纹状体的电解损伤会扰乱游泳的暂时动态，而抗抑郁药会增强这些变化。据推测，阿米替林的特定作用取决于对纹状体起搏器功能的改变。
