Sharifian Mozhgan, Sadeghi Mahdi, Alirezapour Behrouz, Mohseni Morteza
Department of Physics, Payame Noor University, P.O. Box: 19395-3697, Tehran, Iran.
Medical Physics Department, School of Medicine, Iran University of Medical Sciences, P.O. Box: 14155-6183, Tehran, Iran.
Appl Radiat Isot. 2017 Apr;122:136-140. doi: 10.1016/j.apradiso.2017.01.020. Epub 2017 Jan 24.
The radioisotope Y is one of the candidates for the SPECT and Y/Sr generator due to its suitable half-life and decay properties. The proton-induced on the Y target can be used for the production of Y. The present perusal calculated the excitation function for the both Y(p,x)Y direct reaction and decay of Zr via Y(p,3n)Zr → Y → Y indirect reaction using the TALYS-1.8 code. To simulation the production of Y nuclide, the target thickness was designed based on the stopping power calculation by the SRIM-2013 code. The Monte Carlo code GEANT4 was used to simulate the transport of protons through the irradiation assembly. Then, the cumulative integral yield of the Y has been calculated directly after the decay of Zr radionuclide entirely. These results were in good agreement with the theoretical and reported experimental data. Eventually, the integral yield of the Y was calculated by the indirect method from Zr decay after separation the zirconium. This work provides the basis for theoretical appraisement of the use of no-carrier-added Y as radiopharmaceutical for the purpose of medical applications.
放射性同位素钇因其合适的半衰期和衰变特性，是单光子发射计算机断层扫描（SPECT）及钇/锶发生器的候选材料之一。用质子轰击钇靶可用于生产钇。本研究使用TALYS-1.8代码计算了钇（p，x）钇直接反应以及通过锆（p，3n）锆→钇→钇间接反应衰变产生钇的激发函数。为模拟钇核素的生产，基于SRIM-2013代码计算的阻止本领设计了靶厚度。使用蒙特卡罗代码GEANT4模拟质子在辐照组件中的传输。然后，在锆放射性核素完全衰变后直接计算钇的累积积分产额。这些结果与理论和报道的实验数据吻合良好。最终，通过分离锆后由锆衰变的间接方法计算钇的积分产额。这项工作为将无载体添加钇用作医用放射性药物的理论评估提供了依据。
