Sigman Mark
Warren Alpert Medical School of Brown University and the Miriam and Rhode Island Hospitals, Providence, Rhode Island.
Fertil Steril. 2017 Feb;107(2):299-300. doi: 10.1016/j.fertnstert.2016.12.020.
Increasing numbers of men are attempting conception at older ages. Adverse changes in male fertility and sexual function occur with age. In addition, there are potential consequences for children born to older fathers-some medical and some psychological. This month's Views and Reviews section discusses the biologic changes in reproductive function, medical conditions that increase with age that affect reproductive function, the risks to children of older fathers, genetic mechanisms responsible for these risks, and issues clinicians should know to be able to counsel these couples.
越来越多的男性试图在高龄时生育。男性生育能力和性功能会随着年龄增长而出现不良变化。此外，父亲年龄较大时所生孩子也会有一些潜在后果，包括一些医学方面的和心理方面的。本月的“观点与评论”部分讨论了生殖功能的生物学变化、随着年龄增长而增加且影响生殖功能的医学状况、高龄父亲所生孩子面临的风险、导致这些风险的遗传机制，以及临床医生为这些夫妇提供咨询时应该了解的问题。
