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父亲的年龄会太大吗?

Can a father be too old?

作者信息

Eisenberg Michael L

机构信息

Department of Urology, Stanford University School of Medicine, Palo Alto, California; Department of Obstetrics and Gynecology, Stanford University School of Medicine, Palo Alto, California.

出版信息

Fertil Steril. 2022 Dec;118(6):999-1000. doi: 10.1016/j.fertnstert.2022.09.021. Epub 2022 Oct 26.

DOI:10.1016/j.fertnstert.2022.09.021
PMID:36307289
Abstract

This month's Views and Reviews examines the current evidence regarding the association between a man's age and his reproductive health. Wood and Goriely review the link between paternal age and de novo mutations. Zweifel and Woodward expand on the implications to the offspring of older fathers by exploring the neurodevelopmental syndromes that become more prevalent in children of older fathers. Finally, Jimbo et al. examines the association between paternal age and several measures of male fertility including semen quality, birth rates, and assisted reproductive technology success rates.

摘要

本月的“观点与评论”探讨了有关男性年龄与其生殖健康之间关联的现有证据。伍德和戈里利回顾了父亲年龄与新生突变之间的联系。茨韦费尔和伍德沃德通过探究在父亲年龄较大的孩子中更为普遍的神经发育综合征,进一步阐述了父亲年龄较大对后代的影响。最后,吉姆博等人研究了父亲年龄与男性生育能力的几项指标之间的关联,包括精液质量、出生率和辅助生殖技术成功率。

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1
Can a father be too old?父亲的年龄会太大吗?
Fertil Steril. 2022 Dec;118(6):999-1000. doi: 10.1016/j.fertnstert.2022.09.021. Epub 2022 Oct 26.
2
Introduction: What to do with older prospective fathers: the risks of advanced paternal age.引言:高龄准父亲该怎么办:父亲年龄偏大的风险
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Impact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring.高龄父亲对生育能力和后代遗传疾病风险的影响。
Genes (Basel). 2023 Feb 14;14(2):486. doi: 10.3390/genes14020486.
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Relationship between male age, semen parameters and assisted reproductive technology outcomes.男性年龄、精液参数与辅助生殖技术结局的关系。
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Management and counseling of the male with advanced paternal age.高龄男性的管理与咨询
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What does not kill you makes you stronger? Effects of paternal age at conception on fathers and sons.是什么造就了更强的你?受孕时父亲年龄对父子双方的影响。
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引用本文的文献

1
Reproductive toxicology: keeping up with our changing world.生殖毒理学:跟上我们不断变化的世界。
Front Toxicol. 2024 Oct 11;6:1456687. doi: 10.3389/ftox.2024.1456687. eCollection 2024.
2
Reproductive Ageing: Current insights and a potential role of NAD in the reproductive health of aging fathers and their children.生殖衰老:当前的见解和 NAD 在衰老父亲及其子女生殖健康中的潜在作用。
Reproduction. 2024 Apr 29;167(6). doi: 10.1530/REP-23-0486. Print 2024 Jun 1.