Jaipur National University, Jagatpura, Jaipur, India; Sinhgad Institute of Pharmacy, Narhe, Pune, India.
National Chemical Laboratory (NCL), Pune, India.
Bioorg Chem. 2017 Feb;70:256-266. doi: 10.1016/j.bioorg.2017.01.006. Epub 2017 Jan 18.
A novel series of substituted N-(2-(2,3-dioxoindolin-1-yl)acetyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide was designed, synthesized and evaluated for in vitro Reverse Transcriptase (RT) inhibitory activity. This series is a combination of peculiar structural features from leading scaffolds of [(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) and oxyindole. In vitro screening led to identification of two hybrids (9c and 9d) possessing higher RT inhibitory activity than the standard rilpivirine. Docking study was performed to study the binding orientations of synthesized hybrids towards RT enzyme.
设计、合成并评价了一系列新型取代的 N-(2-(2,3-二氧代吲哚啉-1-基)乙酰基)-2-氧代-1,2,3,4-四氢嘧啶-5-甲酰胺，用于体外逆转录酶 (RT) 抑制活性。该系列结合了 [(2-羟乙氧基)甲基]-6-(苯硫基)胸腺嘧啶 (HEPT) 和氧吲哚的独特结构特征。体外筛选鉴定出两个具有比标准利匹韦林更高的 RT 抑制活性的杂种（9c 和 9d）。进行对接研究以研究合成杂种与 RT 酶的结合取向。
