Gok Oguz Ebru, Akoglu Hadim, Ulusal Okyay Gulay, Karaveli Gursoy Guner, Yildirim Tolga, Merhametsiz Ozgur, Cimen Tolga, Canbakan Basol, Yeter Ekrem, Ayli M Deniz
Diskapi Yildirim Beyazit Education and Research Hospital, Department of Nephrology, Ankara, Turkey.
Diskapi Yildirim Beyazit Education and Research Hospital, Department of Nephrology, Ankara, Turkey.
Nefrologia. 2017 Mar-Apr;37(2):189-194. doi: 10.1016/j.nefro.2016.11.013. Epub 2017 Feb 1.
Renalase, with possible monoamine oxidase activity, is implicated in degradation of catecholamines; which suggests novel mechanisms of cardiovascular complications in patients with chronic kidney diseases. Epicardial adipose tissue (EAT) has been found to correlate with cardiovascular diseases (CVD) in dialysis patients. The present study aimed to evaluate the association of serum renalase levels with EAT thickness and other CVD risk factors in peritoneal dialysis (PD) patients.
The study included 40 PD patients and 40 healthy controls. All subjects underwent blood pressure and anthropometric measurements. Serum renalase was assessed by using a commercially available assay. Transthoracic echocardiography was used to measure EAT thickness and left ventricular mass index (LVMI) in all subjects.
The median serum renalase level was significantly higher in the PD patients than in the control group [176.5 (100-278.3) vs 122 (53.3-170.0)ng/ml] (p=0.001). Renalase was positively correlated with C-reactive protein (r=0.705, p<0.001) and negatively correlated with RRF (r=-0.511, p=0.021). No correlation was observed between renalase and EAT thickness or LVMI. There was a strong correlation between EAT thickness and LVMI in both the PD patients and the controls (r=0.848, p<0.001 and r=0.640, p<0.001 respectively).
This study indicates that renalase is associated with CRP and residual renal function but not with EAT thickness as CVD risk factors in PD patients.
肾酶可能具有单胺氧化酶活性，参与儿茶酚胺的降解；这提示了慢性肾脏病患者心血管并发症的新机制。已发现心外膜脂肪组织（EAT）与透析患者的心血管疾病（CVD）相关。本研究旨在评估腹膜透析（PD）患者血清肾酶水平与EAT厚度及其他CVD危险因素之间的关联。
本研究纳入40例PD患者和40例健康对照者。所有受试者均接受血压和人体测量。采用市售检测方法评估血清肾酶。所有受试者均采用经胸超声心动图测量EAT厚度和左心室质量指数（LVMI）。
PD患者血清肾酶水平中位数显著高于对照组[176.5（100 - 278.3）对122（53.3 - 170.0）ng/ml]（p = 0.001）。肾酶与C反应蛋白呈正相关（r = 0.705，p < 0.001），与残余肾功能呈负相关（r = -0.511，p = 0.021）。未观察到肾酶与EAT厚度或LVMI之间存在相关性。PD患者和对照组的EAT厚度与LVMI之间均存在强相关性（分别为r = 0.848，p < 0.001和r = 0.640，p < 0.001）。
本研究表明，在PD患者中，肾酶与CRP和残余肾功能相关，但与作为CVD危险因素的EAT厚度无关。
