Novikov V V, Trofimova M N, Dubinkin I V, Komarova O B, Biriukova L Z
Zh Mikrobiol Epidemiol Immunobiol. 1989 Jul(7):81-4.
Outbred laboratory mice, pretreated with an ascites-forming stimulator and an irradiation dose of 6 Gy, can be used for the production of monoclonal antibodies. However, the passage of hybridomas in irradiated outbred mice rapidly leads to the death of the cells. The properties of antibodies obtained from ascitic fluid of outbred mice are no different from those of antibodies obtained from BALB/c mice.
经腹水形成刺激剂预处理并接受6 Gy辐照剂量的远交系实验小鼠可用于单克隆抗体的制备。然而，杂交瘤在辐照后的远交系小鼠体内传代很快会导致细胞死亡。从远交系小鼠腹水中获得的抗体特性与从BALB/c小鼠中获得的抗体特性并无差异。
