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重症肌无力的相关疾病:自身免疫性疾病及其与胸腺切除术的关系。

Associated disorders in myasthenia gravis: autoimmune diseases and their relation to thymectomy.

作者信息

Thorlacius S, Aarli J A, Riise T, Matre R, Johnsen H J

机构信息

Department of Neurology, University of Bergen, Norway.

出版信息

Acta Neurol Scand. 1989 Oct;80(4):290-5. doi: 10.1111/j.1600-0404.1989.tb03881.x.

DOI:10.1111/j.1600-0404.1989.tb03881.x
PMID:2816285
Abstract

The prevalence of myasthenia gravis (MG) in the counties of Hordaland and Sogn & Fjordane on January 1, 1984 was 9.6 per 100,000 inhabitants. Other autoimmune diseases were found in 11 out of 48 MG patients. The occurrence of autoimmune thyroiditis (5 patients, 10.4%) and systemic lupus erythematosus (4 patients, 8.3%) in the MG patients was clearly higher than that reported in the general population. Rheumatoid arthritis was found in 2 patients (4.2%). The autoimmune diseases were mainly recorded among the nonthymectomized MG patients. In addition to those with definite diseases of autoimmune nature, 3 other MG patients had thyroid antibodies and 1 had antinuclear factor without clinical evidence of autoimmune disease. Seven MG patients (14.6%) had unspecific arthralgia during active periods of MG. Two MG patients had ankylosing spondylitis.

摘要

1984年1月1日,霍达兰郡和松恩-菲尤拉讷郡重症肌无力(MG)的患病率为每10万居民中有9.6人。48例MG患者中有11例患有其他自身免疫性疾病。MG患者中自身免疫性甲状腺炎(5例,10.4%)和系统性红斑狼疮(4例,8.3%)的发生率明显高于普通人群报告的发生率。2例患者(4.2%)患有类风湿性关节炎。自身免疫性疾病主要记录在未行胸腺切除术的MG患者中。除了那些患有明确自身免疫性疾病的患者外,另外3例MG患者有甲状腺抗体,1例有抗核因子,但无自身免疫性疾病的临床证据。7例MG患者(14.6%)在MG活动期有非特异性关节痛。2例MG患者患有强直性脊柱炎。

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