重症肌无力患者在危象期间接受大剂量静脉注射免疫球蛋白时血浆C3c的变化。

Plasma C3c changes in myasthenia gravis patients receiving high-dose intravenous immunoglobulin during crisis.

作者信息

Kamolvarin N, Hemachudha T, Ongpipattanakul B, Phanuphak P, Viddayakorn P, Sueblinvong T

机构信息

Department of Medicine and Biochemistry, Faculty of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand.

出版信息

Acta Neurol Scand. 1989 Oct;80(4):324-6. doi: 10.1111/j.1600-0404.1989.tb03887.x.

DOI:10.1111/j.1600-0404.1989.tb03887.x

PMID:2816289

Abstract

Fast-migrating C3c, a sensitive index of complement activation, was assayed in the plasma of 2 myasthenia gravis (MG) patients in crisis who received high-dose IV immunoglobulin therapy. Dramatic responses were observed in both patients. Clinical improvement paralleled a decrement in C3c levels, suggesting that regulation of complement activation may be one possible mechanism of IV immunoglobulin treatment in MG.

摘要

快速迁移的C3c是补体激活的敏感指标，在2例接受大剂量静脉注射免疫球蛋白治疗的重症肌无力（MG）危象患者的血浆中进行了检测。两名患者均观察到显著反应。临床改善与C3c水平下降平行，提示补体激活的调节可能是静脉注射免疫球蛋白治疗MG的一种可能机制。