Horner K C, Aurousseau C, Erre J P, Cazals Y
Laboratoire d'Audiologie Expérimentale, Inserm Unité 229, Université Bordeaux II, Hôpital Pellegrin, France.
Acta Otolaryngol. 1989 Sep-Oct;108(3-4):175-83. doi: 10.3109/00016488909125516.
Long-term treatment of guinea pigs with the diuretics chlorthalidone and acetazolamide, following the experimental obstruction of the endolymphatic duct, was assessed using chronically implanted round window cochlear electrodes. The diuretic chlorthalidone appeared to curb the progressive low-frequency sensitivity loss during the first 4 weeks following surgery, as compared with animals receiving the diuretic acetazolamide or no treatment. However, this apparent beneficial effect decreased after 4 weeks and was not apparent at 14 weeks post-induction. On the other hand, morphological control at the end of 14 weeks confirmed a marked reduction in hydrops in the chlorthalidone-treated animals. The data clearly demonstrate a dissociation between hydrops and the development of hearing loss and suggest that the augmenting endolymph volume is only one of several contributing factors to the deteriorating auditory function in experimental hydrops.
在内淋巴囊实验性阻塞后，使用长期植入的圆窗耳蜗电极评估了用利尿剂氯噻酮和乙酰唑胺对豚鼠进行长期治疗的效果。与接受利尿剂乙酰唑胺或未接受治疗的动物相比，利尿剂氯噻酮似乎在术后的前4周抑制了低频敏感性的进行性丧失。然而，这种明显的有益效果在4周后减弱，在诱导后14周时并不明显。另一方面，14周结束时的形态学对照证实，氯噻酮治疗的动物内淋巴积水明显减少。数据清楚地表明了积水与听力损失发展之间的分离，并表明内淋巴液体积的增加只是实验性积水导致听觉功能恶化的几个因素之一。
