Kaymakamzade Bahar, Selcuk Ferda, Koysuren Aydan, Colpak Ayse Ilksen, Mut Senem Ertugrul, Kansu Tulay
Department of Neurology, Dr. Burhan Nalbantoglu State Hospital, Nicosia Northern Cyprus Cyprus.
Department of Neurology, School of Medicine, Hacettepe University Ankara Turkey.
Neuroophthalmology. 2013 May 31;37(3):111-115. doi: 10.3109/01658107.2013.792356. eCollection 2013.
Miller Fisher Syndrome is characterised by the classical triad of ophthalmoplegia, ataxia, and areflexia. Ophthalmoparesis without ataxia, without areflexia, or with neither have been attributed as atypical forms of MFS. We report two patients with MFS who had tonic pupils and raised anti-GQ1b antibody titres. Bilateral dilated pupils (either tonic or fixed) can be a manifestation of MFS and anti-GQ1b immunoglobulin G (IgG) antibodies are useful to confirm the diagnosis in unexplained cases. The site of involvement is thought to be the ciliary ganglion or short ciliary nerves.
米勒-费希尔综合征的特征为眼肌麻痹、共济失调和无反射这一经典三联征。无共济失调、无反射或两者皆无的眼肌麻痹被认为是米勒-费希尔综合征的非典型形式。我们报告了两名患有米勒-费希尔综合征的患者，他们有强直性瞳孔且抗GQ1b抗体滴度升高。双侧瞳孔散大（强直性或固定性）可能是米勒-费希尔综合征的一种表现，抗GQ1b免疫球蛋白G（IgG）抗体有助于确诊不明原因的病例。受累部位被认为是睫状神经节或睫状短神经。
