Effects of Different Pediatric Drugs on the Color Stability of Various Restorative Materials Applicable in Pediatric Dentistry.

. The chronic recommendation of pediatric drugs could exhibit erosive and cariogenic problems. . To evaluate the effects of different pediatric drugs on the color stability of various restorative materials. . Five specimens (1 mm × 3 mm) were prepared and immersed in ten different pediatric drugs and agitated every 8 hours daily for 2 min up to 1 week. Between immersion periods, the samples were stored in artificial saliva. After 1-week period, Δ values were calculated. Two-way ANOVA and Fisher's LSD test were used for statistical analysis at a level of < 0.05. . Δ values were only significantly influenced by restorative material factor ( < 0.001) and varied in the range of 2.08 and 6.55 units for all drugs/restorative materials. The highest Δ was found in Ferrosanol B-composite (6.55 ± 1.38) and the lowest one was found in Dolven-glass ionomer (2.08 ± 0.40) pairwise. The most prominent Δ value elevations were obtained in composite material compared to the compomer and/or glass ionomers in Macrol, Ferrosanol B, and Ventolin ( < 0.001; for all) and also for other drugs ( < 0.05). Dolven exhibited significantly higher values compared to Augmentin ( = 0.021), Macrol ( = 0.018), and Ventolin ( = 0.013) in compomer group. . The clinically perceptible color changes for tested composite/pediatric drug pairwise can be more problematic than compomer and glass ionomers in pediatric dentistry.