高剂量缓释铁糖浆对乳牙的外源性牙齿染色潜力。
Extrinsic tooth staining potential of high dose and sustained release iron syrups on primary teeth.
作者信息
Pani Sharat Chandra, Alenazi Fahad Murdhi, Alotain Abdullah Muhammad, Alanazi Hamad Daher, Alasmari Abdullah Saeed
机构信息
Pediatric and Preventive Dentistry, Riyadh Colleges of Dentistry and Pharmacy, Riyadh, Saudi Arabia.
Department of Preventive Dental Sciences, PO Box 84891, Riyadh, 11681, Kingdom of Saudi Arabia.
出版信息
BMC Oral Health. 2015 Aug 4;15:90. doi: 10.1186/s12903-015-0072-0.
BACKGROUND
Iron in the form of oral supplements is routinely prescribed to children to help fight anemia, however tooth staining is a commonly reported complication. This study tests in vitro, the staining potential of two different forms of iron syrup on primary teeth.
METHODS
Forty caries free primary central incisors were divided into four groups of ten teeth each. The control group comprised of ten teeth immersed in artificial saliva, while the test solutions were comprised of different forms of iron mixed with vitamins such that the iron content of each solution was approximately 100 mg (from 100 to 101.1 mg). The test solutions used iron syrup (Ferrose®, SPIMACO, Jeddah, Saudi Arabia) with iron in the form of ferric oxide polymaltose (FOP), slow release formula (Ferroglobin®, Vitabiotics ltd., London, UK) containing ferrous fumarate (FF and a combination of the two (FOP + FF). All the teeth were then immersed for 72 h and subjected to a protocol developed by Lee et al. to test staining. Color changes were measured using a wave dispersion spectro-photometer (Color-Eye 7000A, X-Rite Gmbh, Regensdorf, Switzerland) on the exposed labial surface at 4, 8, 24, 48 and 72 h. Two-way ANOVA with Scheffe's post hoc test was used to determine significance of difference in shade, while the Kurskull-Wallis test used to determine the significance of difference in clinical staining (∆E > 3).
RESULTS
While all three iron groups showed some amount of staining, the combination of the two forms of iron (FOP+FF) showed significantly lower incidence of clinical staining than the other two groups at the end of 72 h. At the end of 72 h the (FOP) had significantly higher ∆E than ferrous fumarate (FF ) while the combination (FOP+ FF) had a significantly lower ∆E than either group.
CONCLUSION
In an in vitro model, combining different forms of iron seems to elicit a lower intensity of staining than equivalent doses of a single form of iron.
背景
口服补充铁剂常用于治疗儿童贫血，但牙齿染色是常见的并发症。本研究在体外测试了两种不同形式的铁糖浆对乳牙的染色潜力。
方法
40颗无龋的乳中切牙被分为四组，每组10颗牙。对照组由10颗浸泡在人工唾液中的牙齿组成，测试溶液由不同形式的铁与维生素混合而成，使每种溶液中的铁含量约为100毫克（100至101.1毫克）。测试溶液使用了以聚麦芽糖铁（FOP）形式存在铁的铁糖浆（Ferrose®，SPIMACO，吉达，沙特阿拉伯）、含有富马酸亚铁（FF）的缓释配方（Ferroglobin®，Vitabiotics ltd.，伦敦，英国）以及两者的组合（FOP + FF）。然后将所有牙齿浸泡72小时，并按照Lee等人制定的方案进行染色测试。在4、8、24、48和72小时时，使用波色散分光光度计（Color-Eye 7000A，X-Rite Gmbh，雷根斯多夫，瑞士）测量暴露唇面的颜色变化。使用双向方差分析和Scheffe事后检验来确定色调差异的显著性，而使用Kurskull-Wallis检验来确定临床染色差异的显著性（∆E > 3）。
结果
虽然所有三个铁组都有一定程度的染色，但在72小时结束时，两种铁形式的组合（FOP + FF）的临床染色发生率明显低于其他两组。在72小时结束时，（FOP）的∆E明显高于富马酸亚铁（FF），而组合（FOP + FF）的∆E明显低于任何一组。
结论
在体外模型中，与等量单一形式的铁相比，不同形式的铁组合似乎导致较低的染色强度。
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