Institute of Sport Sciences and Physiotherapy, Faculty of Medicine, University of Tartu, Tartu, Estonia.
Children's Clinic of Tartu University Hospital, Tartu, Estonia.
Obesity (Silver Spring). 2017 Mar;25(3):600-607. doi: 10.1002/oby.21756. Epub 2017 Feb 6.
Serum inflammatory markers could help to identify those boys with overweight (OWB) who gain weight more extensively during puberty. This study aimed to examine the longitudinal changes in different serum inflammatory markers through puberty in boys with different BMI values and increments.
Twenty-six OWB and 29 normal-weight boys (NWB) were followed yearly for 3 years to measure changes in BMI and serum concentrations of 12 inflammatory markers.
OWB had higher (P < 0.033) baseline interleukin (IL)-6, IL-8, interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), and IL-1α concentrations in comparison with NWB. Over the 3-year period, IFN-γ (P = 0.0001) and TNF-α (P = 0.0042) decreased more in OWB compared to NWB. Serum IL-8, monocyte chemoattractant protein (MCP)-1, and leptin increased further in those OWB who gained BMI more extensively through puberty compared to OWB who gained weight at slower rates (P < 0.033).
Serum IFN-γ and TNF-α levels decreased more during pubertal years in OWB compared to NWB, indicating that pubertal maturation itself may have a favorable impact on the inflammation of obesity. Serum IL-8, MCP-1, and leptin could help to identify OWB who gain BMI more extensively during pubertal years.
血清炎症标志物有助于识别超重（OWB）男孩在青春期体重增长更为广泛的情况。本研究旨在通过青春期，检查不同 BMI 值和体重增加幅度的男孩血清中不同炎症标志物的纵向变化。
26 名 OWB 和 29 名正常体重男孩（NWB）每年随访 3 年，以测量 BMI 和 12 种炎症标志物的血清浓度变化。
OWB 的白细胞介素（IL）-6、IL-8、干扰素γ（IFN-γ）、肿瘤坏死因子α（TNF-α）和 IL-1α浓度基线高于 NWB（P < 0.033）。在 3 年期间，与 NWB 相比，OWB 中 IFN-γ（P = 0.0001）和 TNF-α（P = 0.0042）的下降更为明显。与体重增长较慢的 OWB 相比，在青春期体重增长更为广泛的 OWB 中，血清 IL-8、单核细胞趋化蛋白 1（MCP-1）和瘦素进一步增加（P < 0.033）。
与 NWB 相比，OWB 中血清 IFN-γ和 TNF-α水平在青春期下降更为明显，这表明青春期成熟本身可能对肥胖炎症有积极影响。血清 IL-8、MCP-1 和瘦素有助于识别在青春期体重增长更为广泛的 OWB。
