Chen Xin-Ping, Xu Da-Feng, Xu Wei-Hua, Ma Zhi-Chao, Yao Jia, Fu Sheng-Miao
Clin Lab. 2016 Sep 1;62(9):1795-1802. doi: 10.7754/Clin.Lab.2016.160132.
Although many epidemiological studies have investigated the CYP1A1 exon7 polymorphism and -GSTM1 interaction with esophageal cancer (EC), definite conclusions cannot be drawn. This study was conducted to explore this association in the Chinese population using meta-analysis.
Relevant studies were identified from PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine databases published through August 2015. The association of CYP1A1 exon7 polymorphisms and EC risk was estimated by odds ratio (ORs) with 95% confidence intervals (CIs). In addition, the interaction between the CYP1A1 exon7 and GSTM1 genotypes was assessed.
A total of 13 case-control studies including 1781 EC cases and 1996 controls were included in this metaanalysis. Overall, significantly increased EC risk was associated with the CYP1A1 exon7 polymorphism (G vs. A OR = 1.36, 95% CI = 1.14 - 1.64; GG vs. AA: OR = 1.85, 95% CI = 1.22 - 2.79; GG vs. AG: OR = 1.41, 95% CI = 1.01 - 1.96; GG + AG vs. AA: OR = 1.47, 95% CI = 1.28 - 1.68; GG vs. AA + AG: OR = 1.60, 95% CI = 1.10 - 2.31). In a subgroup analyses stratified by geographic areas, histopathology type and source of controls, the significant risk was found in hospital-based population, in South and North China. Analysis of CYP1A1- GSTM1 interaction did find synergistic interaction between these two genes.
This meta-analysis provides the evidence that CYP1A1 exon7 polymorphism may contribute to the EC development in the Chinese population, and CYP1A1- GSTM1 interaction might elevate the risk.
尽管许多流行病学研究已对CYP1A1基因第7外显子多态性及谷胱甘肽硫转移酶M1（GSTM1）与食管癌（EC）的相互作用进行了调查，但仍无法得出明确结论。本研究通过荟萃分析探讨中国人群中的这种关联。
从PubMed、Springer Link、Ovid、中国万方数据知识服务平台、中国知网和中国生物医学数据库中检索截至2015年8月发表的相关研究。采用比值比（OR）及95%置信区间（CI）评估CYP1A1基因第7外显子多态性与食管癌风险的关联。此外，还评估了CYP1A1基因第7外显子与GSTM1基因型之间的相互作用。
本荟萃分析共纳入13项病例对照研究，包括1781例食管癌病例和1996例对照。总体而言，CYP1A1基因第7外显子多态性与食管癌风险显著增加相关（G与A比较：OR = 1.36，95%CI = 1.14 - 1.64；GG与AA比较：OR = 1.85，95%CI = 1.22 - 2.79；GG与AG比较：OR = 1.41，95%CI = 1.01 - 1.96；GG + AG与AA比较：OR = 1.47，95%CI = 1.28 - 1.68；GG与AA + AG比较：OR = 1.60，95%CI = 1.10 - 2.31）。在按地理区域、组织病理学类型和对照来源分层的亚组分析中，发现基于医院的人群、中国南方和北方存在显著风险。对CYP1A1 - GSTM1相互作用的分析确实发现这两个基因之间存在协同相互作用。
本荟萃分析提供了证据表明CYP1A1基因第7外显子多态性可能与中国人群食管癌的发生有关，且CYP1A1 - GSTM1相互作用可能会增加风险。
