Ghoshal Uday C, Ghoshal Ujjala
Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India.
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India.
Gastroenterol Clin North Am. 2017 Mar;46(1):103-120. doi: 10.1016/j.gtc.2016.09.008.
Gut microbiota is the largest organ of the human body. Although growth of bacteria more than 10 colony forming unit (CFU) per milliliter in culture of upper gut aspirate is used to diagnosis small intestinal bacterial overgrowth (SIBO), 10 CFU or more is being considered to suggest the diagnosis, particularly if colonic type bacteria are present in the upper gut. Although neither very sensitive nor specific, hydrogen breath tests are widely used to diagnose SIBO. Rifaximin is the best treatment for SIBO due to its broad spectrum, lack of systemic absorption, and safety profile.
肠道微生物群是人体最大的器官。虽然上消化道吸出物培养中每毫升细菌生长超过10个菌落形成单位（CFU）用于诊断小肠细菌过度生长（SIBO），但目前认为10 CFU或更多即提示诊断，尤其是当上消化道中存在结肠型细菌时。虽然氢呼气试验既不非常敏感也不特异，但它被广泛用于诊断SIBO。利福昔明因其广谱、无全身吸收及安全性等特点，是治疗SIBO的最佳药物。
