Costoya Alejandro, Concheiro Angel, Alvarez-Lorenzo Carmen
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, R+D Pharma Group (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15872 Santiago de Compostela, Spain.
Molecules. 2017 Feb 3;22(2):230. doi: 10.3390/molecules22020230.
Cyclodextrins (CDs) can endow electrospun fibers with outstanding performance characteristics that rely on their ability to form inclusion complexes. The inclusion complexes can be blended with electrospinnable polymers or used themselves as main components of electrospun nanofibers. In general, the presence of CDs promotes drug release in aqueous media, but they may also play other roles such as protection of the drug against adverse agents during and after electrospinning, and retention of volatile fragrances or therapeutic agents to be slowly released to the environment. Moreover, fibers prepared with empty CDs appear particularly suitable for affinity separation. The interest for CD-containing nanofibers is exponentially increasing as the scope of applications is widening. The aim of this review is to provide an overview of the state-of-the-art on CD-containing electrospun mats. The information has been classified into three main sections: (i) fibers of mixtures of CDs and polymers, including polypseudorotaxanes and post-functionalization; (ii) fibers of polymer-free CDs; and (iii) fibers of CD-based polymers (namely, polycyclodextrins). Processing conditions and applications are analyzed, including possibilities of development of stimuli-responsive fibers.
环糊精（CDs）能够赋予电纺纤维优异的性能特性，这依赖于它们形成包合物的能力。包合物可以与可电纺聚合物混合，或者自身用作电纺纳米纤维的主要成分。一般来说，CDs的存在会促进药物在水性介质中的释放，但它们也可能发挥其他作用，比如在电纺过程中和电纺后保护药物免受不良因素影响，以及保留挥发性香料或治疗剂以便缓慢释放到环境中。此外，用空CDs制备的纤维似乎特别适合亲和分离。随着应用范围的不断扩大，对含CD纳米纤维的兴趣呈指数级增长。本综述的目的是概述含CD电纺垫的最新研究状况。相关信息已分为三个主要部分：（i）CDs与聚合物的混合物纤维，包括聚准轮烷和后功能化；（ii）无聚合物CDs纤维；（iii）基于CD的聚合物（即聚环糊精）纤维。分析了加工条件和应用，包括开发刺激响应性纤维的可能性。
